Chick J
Out-Patients Department, Royal Edinburgh Hospital, UK.
Alcohol Alcohol. 1995 Nov;30(6):785-7.
Acamprostate is a gamma-aminobutyric acid (GABA) analogue for which evidence is accumulating of a clinically useful benefit when used as an adjunct for conventional treatments to prevent relapse in alcohol dependence. This paper reviews published randomized controlled studies involving 1304 patients. To date no abstinence syndrome associated with acamprostate has been identified nor serious adverse effects. It is not effective in all patients, and the characteristics of the individuals most likely to respond and the treatment setting and modalities in which it is likely to be most helpful, have yet to be specified.
阿坎酸是一种γ-氨基丁酸（GABA）类似物，越来越多的证据表明，当用作传统治疗的辅助药物以预防酒精依赖复发时，它具有临床实用价值。本文回顾了涉及1304名患者的已发表随机对照研究。迄今为止，尚未发现与阿坎酸相关的戒断综合征或严重不良反应。它并非对所有患者都有效，最可能有反应的个体特征以及最可能从中受益的治疗环境和方式尚未明确。
