Kaye J N, Starkey W G, Kell B, Biswas C, Raju K S, Best J M, Cason J
Richard Dimbleby Laboratory of Cancer Virology, Department of Virology, Rayne Institute, London, UK.
J Gen Virol. 1996 Jun;77 ( Pt 6):1139-43. doi: 10.1099/0022-1317-77-6-1139.
Perinatal transmission of human papillomavirus type 16 (HPV-16) and persistence of virus DNA in infants until 6 months of age has been described. To confirm the origin of infant infections as maternal, we determined the nucleotide sequence of the upstream regulatory region (URR; bp 7540 to 157) of HPV-16 in samples from 13 HPV-16 DNA-positive mothers and their infants at 6 weeks and 2 years of age. Identical HPV-16 variant URR sequences were found in two mother/infant samples and similar variants were found in three sets. Four mothers with samples which contained prototypic HPV-16 sequences delivered infants who also had the prototypic sequence. Four mothers with variant URRs delivered infants who harboured either prototypic or different URR variants. Thus, concordant variants or prototypic sequences were detected in nine of 13 mother/infant samples, indicating that up to 69.2% of HPV-16-positive infants acquire virus from their mothers.
已有关于人乳头瘤病毒16型（HPV - 16）围产期传播以及病毒DNA在婴儿体内持续存在至6个月龄的描述。为了证实婴儿感染的源头是母亲，我们测定了13名HPV - 16 DNA阳性母亲及其6周龄和2岁婴儿样本中HPV - 16上游调控区（URR；第7540至157碱基对）的核苷酸序列。在两份母婴样本中发现了相同的HPV - 16变异型URR序列，在三组样本中发现了相似的变异型。四名样本中含有HPV - 16原型序列的母亲所生婴儿也具有该原型序列。四名具有变异型URR的母亲所生婴儿携带的要么是原型序列，要么是不同的URR变异型。因此，在13份母婴样本中的9份中检测到了一致的变异型或原型序列，这表明高达69.2%的HPV - 16阳性婴儿从其母亲那里获得病毒。
