Smith Elaine M, Parker Michael A, Rubenstein Linda M, Haugen Thomas H, Hamsikova Eva, Turek Lubomir P
Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA.
Infect Dis Obstet Gynecol. 2010;2010:326369. doi: 10.1155/2010/326369. Epub 2010 Mar 14.
Few large studies have evaluated concordance based on a broad spectrum of human papillomavirus (HPV) types in oral and genital specimens of mothers and their recently born infants. This information is important in determining whether HPV vaccines administered prior to pregnancy may be useful for preventing vertical transmission. HPV DNA was positive in 30% of mothers and 1.5% of newborns. Maternal/newborn concordance (HPV+/+ or HPV-/-) was 71%. Among HPV DNA+ mothers, only 3% of their infants were DNA+ and only 1 pair had the same HPV type. Among HPV- women, 0.8% of infants were HPV+. HPV DNA detected in hospitalized newborns reflects current infection transmitted to infants during pregnancy or delivery. None of the mother/baby HPV DNA+ concordance pairs detected viral types found in HPV vaccines suggesting that vaccination prior to pregnancy is unlikely to be efficacious in preventing vertical transmission.
很少有大型研究基于广泛的人乳头瘤病毒（HPV）类型，对母亲及其新生儿的口腔和生殖器标本进行一致性评估。这些信息对于确定孕前接种HPV疫苗是否有助于预防垂直传播至关重要。30%的母亲和1.5%的新生儿HPV DNA呈阳性。母婴一致性（HPV+/+或HPV-/-）为71%。在HPV DNA呈阳性的母亲中，只有3%的婴儿DNA呈阳性，且只有一对母婴具有相同的HPV类型。在HPV呈阴性的女性中，0.8%的婴儿HPV呈阳性。住院新生儿中检测到的HPV DNA反映了孕期或分娩期间传播给婴儿的当前感染。在检测到的母婴HPV DNA阳性一致性配对中，没有一对发现HPV疫苗中所含的病毒类型，这表明孕前接种疫苗不太可能有效预防垂直传播。
