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黄曲霉产生的环匹阿尼酸及其对肉鸡的影响。

Cyclopiazonic acid production by Aspergillus flavus and its effects on broiler chickens.

作者信息

Dorner J W, Cole R J, Lomax L G, Gosser H S, Diener U L

出版信息

Appl Environ Microbiol. 1983 Sep;46(3):698-703. doi: 10.1128/aem.46.3.698-703.1983.

DOI:10.1128/aem.46.3.698-703.1983
PMID:6416167
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC239337/
Abstract

Cyclopiazonic acid (CPA) was purified from cultures of Aspergillus flavus, and ca. 14 g of the toxin was collected for use in feeding studies. Chicken rations were artificially contaminated with purified CPA at concentrations of 10, 50, and 100 ppm (microgram/g) and fed ad libitum to eight groups of chickens for 7 weeks. Chickens receiving feed with 100 ppm of CPA had high mortality, decreased weight gain, and poor feed conversion when compared with birds receiving other doses. Postmortem examination showed that chickens fed the two greatest doses of CPA had proventricular lesions characterized by mucosal erosion and hyperemia (100 ppm) and by thick mucosa and dilated proventricular lumens (50 ppm). Birds given 100 ppm of CPA in feed also had numerous yellow foci in their livers and spleens. Microscopic examination of tissues of birds that received 100 ppm of CPA revealed ulcerative proventriculitis, mucosal necrosis in the gizzard, and hepatic and splenic necrosis and inflammation. Birds given 50 ppm of CPA had hyperplasia of the proventricular mucosal epithelium. Birds given 10 ppm of CPA and control birds had no significant treatment-related lesions.

摘要

从黄曲霉培养物中纯化出环匹阿尼酸(CPA),收集了约14克该毒素用于饲养研究。将鸡饲料分别用浓度为10、50和100 ppm(微克/克)的纯化CPA进行人工污染,然后随意投喂给八组鸡,持续7周。与接受其他剂量CPA的鸡相比,接受100 ppm CPA饲料的鸡死亡率高、体重增加减少且饲料转化率低。尸检显示,投喂两种最大剂量CPA的鸡腺胃有病变,特征为黏膜糜烂和充血(100 ppm组)以及黏膜增厚和腺胃腔扩张(50 ppm组)。饲料中添加100 ppm CPA的鸡肝脏和脾脏也有许多黄色病灶。对接受100 ppm CPA的鸡组织进行显微镜检查发现有溃疡性腺胃炎、肌胃黏膜坏死以及肝脏和脾脏坏死与炎症。给予50 ppm CPA的鸡腺胃黏膜上皮增生。给予10 ppm CPA的鸡和对照鸡没有与处理相关的明显病变。

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本文引用的文献

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Occurrence of cyclopiazonic acid in peanuts.花生中环匹阿尼酸的存在情况。
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