Petry T, Schmid P, Schlatter C
Institute of Toxicology, Swiss Federal Institute of Technology (ETH) Zurich, Switzerland.
Ann Occup Hyg. 1996 Jun;40(3):345-57. doi: 10.1016/0003-4878(95)00075-5.
Workers in plants producing carbon anodes for aluminium electrolysis are exposed to PAHs containing coal tar pitch volatiles, pitch and coke. The aim of this study was to evaluate the suitability of urinary 1-hydroxypyrene to characterize respiratory exposure to PAH, which is most relevant for assessing individual health risks. Six workers in a carbon anode plant volunteered to take part in a personal air sampling and a biological monitoring programme lasting five consecutive 8-h shifts to determine occupational exposure to airborne PAHs and urinary excretion of 1-hydroxypyrene. Exposure to total PAH for all worksites varied from 3.99 to 120.6 micrograms PAH m-3 and for benzo(a)pyrene (BaP) from 0.17 to 4.88 micrograms BaP m-3. The concentration of 1-hydroxypyrene in post- and pre-shift urine samples was in the range (0.5- 61.8 mumol 1-OHP per mol creatinine) and depended on the worksite. The Spearman rank correlation test showed a low but significant (P<0.005) correlation of urinary 1-hydroxypyrene in the post-and pre-shift samples with respiratory pyrene exposure. The quantitative aspects of biological monitoring for the evaluation of respiratory PAH exposure were tested with a pharmacokinetic model. On the basis of individual pyrene exposure, excretion of urinary 1-hydroxypyrene during the working week was calculated for each worker. The results presented in this investigation indicate that biological monitoring of the pyrene metabolite 1-hydroxypyrene is a useful indicator of a general PAH exposure, but cannot replace personal air sampling for assessing the lung cancer risk of individuals.
从事铝电解用碳阳极生产的工厂工人会接触到含有煤焦油沥青挥发物、沥青和焦炭的多环芳烃。本研究的目的是评估尿中1-羟基芘用于表征呼吸道多环芳烃暴露的适用性，这对于评估个体健康风险最为相关。一家碳阳极工厂的六名工人自愿参加了一项个人空气采样和生物监测计划，该计划持续五个连续的8小时轮班，以确定空气中多环芳烃的职业暴露以及尿中1-羟基芘的排泄情况。所有工作场所的总多环芳烃暴露量在3.99至120.6微克多环芳烃/立方米之间，苯并(a)芘（BaP）的暴露量在0.17至4.88微克BaP/立方米之间。班前和班后尿样中1-羟基芘的浓度范围为（每摩尔肌酐0.5 - 61.8微摩尔1-OHP），且取决于工作场所。Spearman等级相关检验表明，班前和班后尿样中1-羟基芘与呼吸道芘暴露之间存在低但显著（P<0.005）的相关性。用药物动力学模型测试了用于评估呼吸道多环芳烃暴露的生物监测的定量方面。根据个体芘暴露情况，计算了每个工人工作周内尿中1-羟基芘的排泄量。本研究结果表明，对芘代谢物1-羟基芘的生物监测是多环芳烃总体暴露的有用指标，但不能替代个人空气采样来评估个体的肺癌风险。
