Ishii K, Zhen L X, Wang D H, Funamori Y, Ogawa K, Taketa K
Department of Public Health, Okayama University Medical School.
Jpn J Cancer Res. 1996 Jul;87(7):680-4. doi: 10.1111/j.1349-7006.1996.tb00277.x.
Adult male and female acatalasemic (C3H/AnLCsbCsb),hypocatalasemic (C3H/AnLCscCsc) and normal mice of C3H strain fed on regular laboratory chow for 15 months showed an increased incidence of spontaneous mammary tumor in the decreasing order of female acatalasemic, male acatalasemic, female hypocatalasemic and male hypocatalasemic mice. Normal mice did not develop mammary tumor. We conducted a prospective study with female acatalasemic mice, which showed the highest incidence of mammary tumor, to examine the preventive effect of vitamin E on mammary tumor. Female acatalasemic mice were fed on vitamin E-deficient (28 animals) and vitamin E-supplemented diet (25 animals) for 29 months. The incidence of mammary tumor in mice given the vitamin E-supplemented diet was 47%, while that in mice given vitamin E-deficient diet was 82% (P < 0.002). Mammary tumors were apparent after 9 months of vitamin E deprivation and after 14 months of vitamin E supplementation. Female normal mice did not develop mammary tumor during a comparable period of time. The mean catalase activity of mammary gland in acatalasemic mice was 18.8% of that in normal mice. The results indicate that vitamin E protects acatalasemic mice against the development of mammary tumor.
以常规实验室饲料喂养15个月的成年雄性和雌性无过氧化氢酶血症（C3H/AnLCsbCsb）、低过氧化氢酶血症（C3H/AnLCscCsc）的C3H品系小鼠以及正常小鼠，自发性乳腺肿瘤的发生率按雌性无过氧化氢酶血症小鼠、雄性无过氧化氢酶血症小鼠、雌性低过氧化氢酶血症小鼠和雄性低过氧化氢酶血症小鼠的顺序递减。正常小鼠未发生乳腺肿瘤。我们对乳腺肿瘤发生率最高的雌性无过氧化氢酶血症小鼠进行了一项前瞻性研究，以检验维生素E对乳腺肿瘤的预防作用。将雌性无过氧化氢酶血症小鼠分为两组，分别给予维生素E缺乏饮食（28只）和补充维生素E的饮食（25只），持续29个月。给予补充维生素E饮食的小鼠乳腺肿瘤发生率为47%，而给予维生素E缺乏饮食的小鼠乳腺肿瘤发生率为82%（P<0.002）。在缺乏维生素E 9个月后以及补充维生素E 14个月后，乳腺肿瘤明显出现。在相当长的一段时间内，雌性正常小鼠未发生乳腺肿瘤。无过氧化氢酶血症小鼠乳腺中的过氧化氢酶平均活性为正常小鼠的18.8%。结果表明，维生素E可保护无过氧化氢酶血症小鼠免受乳腺肿瘤的发生。
