Mahalingam R, Wellish M, Cohrs R, Debrus S, Piette J, Rentier B, Gilden D H
Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA.
Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2122-4. doi: 10.1073/pnas.93.5.2122.
The ganglionic cell type in which varicella-zoster virus (VZV) is latent in humans was analyzed by using antibodies raised against in vitro-expressed VZV open reading frame 63 protein. VZV open reading frame 63 protein was detected exclusively in the cytoplasm of neurons of latently infected human trigeminal and thoracic ganglia. This is, to our knowledge, the first identification of a herpesvirus protein expressed during latency in the human nervous system.
通过使用针对体外表达的水痘带状疱疹病毒（VZV）开放阅读框63蛋白产生的抗体，分析了VZV在人类中潜伏的神经节细胞类型。VZV开放阅读框63蛋白仅在潜伏感染的人类三叉神经节和胸神经节神经元的细胞质中被检测到。据我们所知，这是首次鉴定出在人类神经系统潜伏期间表达的疱疹病毒蛋白。
