Humphrey R W, O'Brien T R, Newcomb F M, Nishihara H, Wyvill K M, Ramos G A, Saville M W, Goedert J J, Straus S E, Yarchoan R
Medicine Branch National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1906, USA.
Blood. 1996 Jul 1;88(1):297-301.
Herpesvirus-like DNA sequences (KSHV/HHV-8) have recently been described in AIDS-associated Kaposi's sarcoma (KS) lesions. Many questions remain regarding the role of this virus in KS and the therapeutic implications of this finding. In the current study, KSHV/HHV-8 DNA was detected in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus (HIV)-infected patients with KS (34/98) more often than in HIV-infected individuals without KS (12/64, P = .03). The detection of KSHV/HHV-8 DNA did not correlate with the CD4 lymphocyte count. Five patients demonstrated KSHV/HHV-8 DNA in their PBMCs during administration of intravenous foscarnet and/or ganciclovir. The continued detection of KSHV/HHV-8 DNA in the PBMCs of patients receiving these anti-herpesvirus drugs has potential implications regarding the virus-cell relationship of KSHV/HHV-8, as well as for the value of these drugs in treating or preventing KS, but additional studies are needed.
疱疹病毒样DNA序列（卡波西肉瘤相关疱疹病毒/人疱疹病毒8型，KSHV/HHV-8）最近在艾滋病相关的卡波西肉瘤（KS）病变中被发现。关于这种病毒在KS中的作用以及这一发现的治疗意义，仍有许多问题。在当前研究中，在感染人类免疫缺陷病毒（HIV）的KS患者（34/98）的外周血单个核细胞（PBMC）中检测到KSHV/HHV-8 DNA的频率高于未患KS的HIV感染个体（12/64，P = 0.03）。KSHV/HHV-8 DNA的检测与CD4淋巴细胞计数无关。5例患者在静脉注射膦甲酸钠和/或更昔洛韦期间，其PBMC中检测到KSHV/HHV-8 DNA。在接受这些抗疱疹病毒药物治疗的患者的PBMC中持续检测到KSHV/HHV-8 DNA，这对KSHV/HHV-8的病毒-细胞关系以及这些药物在治疗或预防KS中的价值具有潜在意义，但还需要进一步研究。
