Cramer D, Ward S, Geddes D
Lung Function Unit, Royal Brompton Hospital, London, UK.
Thorax. 1996 Feb;51(2):202-3. doi: 10.1136/thx.51.2.202.
The aim of this study was to simulate an in flight environment at sea level with a fractional inspired concentration of oxygen (FiO2) of 0.15 to determine how much supplemental oxygen was needed to restore a subject's oxygen saturation (SaO2) to 90% or to the level previously attained when breathing room air (FiO2 of 0.21).
Three groups were selected with normal, obstructive, and restrictive lung function. Using a sealed body plethysmograph an environment with an FiO2 of 0.15 was created and mass spectrometry was used to monitor the FiO2. Supplemental oxygen was administered to the patient by nasal cannulae. SaO2 was continuously monitored and recorded at an FiO2 of 0.21, 0.15, and 0.15 + supplemental oxygen.
When given 2 l/m of supplemental oxygen all patients in the 15% environment returned to a similar SaO2 value as that obtained using the 21% oxygen environment. One patient with airways obstruction needed 3 l/m of supplemental oxygen to raise his SaO2 above 90%.
This technique, which simulates an aircraft environment, enables an accurate assessment to be made of supplemental oxygen requirements.
本研究的目的是在海平面模拟飞行环境,吸入氧分数(FiO2)为0.15,以确定需要多少补充氧气才能将受试者的血氧饱和度(SaO2)恢复到90%,或恢复到呼吸室内空气(FiO2为0.21)时先前达到的水平。
选择三组肺功能正常、阻塞性和限制性的受试者。使用密封体容积描记器创建FiO2为0.15的环境,并使用质谱法监测FiO2。通过鼻导管向患者提供补充氧气。在FiO2为0.21、0.15和0.15+补充氧气时持续监测并记录SaO2。
在15%的环境中,当给予2升/分钟的补充氧气时,所有患者的SaO2值恢复到与使用21%氧气环境时相似的水平。一名气道阻塞患者需要3升/分钟的补充氧气才能将其SaO2提高到90%以上。
这种模拟飞机环境的技术能够准确评估补充氧气的需求。