运动诱发性哮喘与哮喘儿童的心血管健康状况
Exercise-induced asthma and cardiovascular fitness in asthmatic children.
作者信息
Thio B J, Nagelkerke A F, Ketel A G, van Keeken B L, Dankert-Roelse J E
机构信息
Department of Paediatric Pulmonogy, Academisch Ziekenhuis Vrije Universiteit, Amsterdam, Netherlands.
出版信息
Thorax. 1996 Feb;51(2):207-9. doi: 10.1136/thx.51.2.207.
BACKGROUND
The role of physical training in the management of children with exercise-induced asthma is controversial. A study was undertaken to determine whether a relationship could be found between the occurrence of exercise-induced asthma and the degree of cardiovascular fitness in asthmatic children.
METHODS
Twenty eight children aged 6-13 with mild to moderate asthma and dyspnoea during or after physical exercise were tested. All patients had a basal forced expiratory volume in one second (FEV1) of > 80% predicted. Twelve patients were taking corticosteroid maintenance medication by inhalation and 16 were not. Two exercise tests were performed on a treadmill to assess peak oxygen consumption rate (VO2max) and the percentage decrease in FEV1 after exercise.
RESULTS
There was no correlation between the VO2max and the percentage decrease in FEV1. Patients not taking steroids showed a greater fall in FEV1 than those receiving corticosteroid medication (mean fall in FEV1 28.7% versus 6.6%). Four of the 12 children treated with steroids and two of the 16 children not taking steroids had a level of cardiovascular fitness lower than the 5th percentile for healthy Dutch children.
CONCLUSION
Normal cardiovascular fitness does not prevent exercise-induced asthma.
背景
体育锻炼在运动诱发性哮喘患儿管理中的作用存在争议。开展了一项研究，以确定运动诱发性哮喘的发生与哮喘患儿心血管健康程度之间是否存在关联。
方法
对28名年龄在6至13岁、在体育锻炼期间或之后出现轻度至中度哮喘和呼吸困难的儿童进行了测试。所有患者的一秒用力呼气容积（FEV1）基础值均>预测值的80%。12名患者通过吸入方式服用皮质类固醇维持药物，16名未服用。在跑步机上进行了两项运动测试，以评估峰值耗氧率（VO2max）和运动后FEV1的下降百分比。
结果
VO2max与FEV1的下降百分比之间无相关性。未服用类固醇的患者FEV1下降幅度大于接受皮质类固醇药物治疗的患者（FEV1平均下降幅度分别为28.7%和6.6%）。12名接受类固醇治疗的儿童中有4名，16名未服用类固醇的儿童中有2名，其心血管健康水平低于荷兰健康儿童的第5百分位数。
结论
正常的心血管健康状况并不能预防运动诱发性哮喘。
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