酵母中转录导致简单重复DNA序列不稳定
Destabilization of simple repetitive DNA sequences by transcription in yeast.
作者信息
Wierdl M, Greene C N, Datta A, Jinks-Robertson S, Petes T D
机构信息
Department of Biology, University of North Carolina, Chapel Hill 27599-3280, USA.
出版信息
Genetics. 1996 Jun;143(2):713-21. doi: 10.1093/genetics/143.2.713.
Abstract
Simple repetitive DNA sequences in the eukaryotic genome frequently alter in length. In wild-type strains, we find that transcription through a repetitive poly GT tract destabilizes the tract four- to ninefold. In mismatch repair-deficient yeast strains, simple repeats are very unstable. High levels of transcription in such strains destabilize repetitive tracts an additional two- to threefold.
摘要
真核生物基因组中的简单重复DNA序列长度经常发生改变。在野生型菌株中，我们发现转录通过一个重复的聚GT序列会使该序列的稳定性降低4至9倍。在错配修复缺陷的酵母菌株中，简单重复序列非常不稳定。在此类菌株中的高转录水平会使重复序列的稳定性再降低2至3倍。
相似文献
1
Destabilization of simple repetitive DNA sequences by transcription in yeast.酵母中转录导致简单重复DNA序列不稳定
Genetics. 1996 Jun;143(2):713-21. doi: 10.1093/genetics/143.2.713.
2
Instability of simple sequence DNA in Saccharomyces cerevisiae.酿酒酵母中简单序列DNA的不稳定性。
Mol Cell Biol. 1992 Jun;12(6):2749-57. doi: 10.1128/mcb.12.6.2749-2757.1992.
3
Microsatellite instability in yeast: dependence on repeat unit size and DNA mismatch repair genes.酵母中的微卫星不稳定性：对重复单元大小和DNA错配修复基因的依赖性。
Mol Cell Biol. 1997 May;17(5):2851-8. doi: 10.1128/MCB.17.5.2851.
4
Requirement of the yeast RTH1 5' to 3' exonuclease for the stability of simple repetitive DNA.酵母RTH1 5'至3'核酸外切酶对简单重复DNA稳定性的需求
Science. 1995 Jul 14;269(5221):238-40. doi: 10.1126/science.7618086.
5
Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair.影响DNA错配修复的突变导致酵母中简单重复DNA片段的不稳定。
Nature. 1993 Sep 16;365(6443):274-6. doi: 10.1038/365274a0.
6
Specific transcripts are elevated in Saccharomyces cerevisiae in response to DNA damage.在酿酒酵母中，特定转录本会因DNA损伤而升高。
Mol Cell Biol. 1984 Nov;4(11):2356-63. doi: 10.1128/mcb.4.11.2356-2363.1984.
7
Analysis of microsatellite mutations in the mitochondrial DNA of Saccharomyces cerevisiae.酿酒酵母线粒体DNA微卫星突变分析
Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):250-5. doi: 10.1073/pnas.97.1.250.
8
The stabilization of repetitive tracts of DNA by variant repeats requires a functional DNA mismatch repair system.
Cell. 1995 Nov 17;83(4):539-45. doi: 10.1016/0092-8674(95)90093-4.
9
Stabilization of microsatellite sequences by variant repeats in the yeast Saccharomyces cerevisiae.酿酒酵母中变异重复序列对微卫星序列的稳定作用。
Genetics. 1997 Jun;146(2):491-8. doi: 10.1093/genetics/146.2.491.
10
Internal tracts of telomeric DNA act as silencers in Saccharomyces cerevisiae.端粒DNA的内部区域在酿酒酵母中起到沉默子的作用。
Genes Dev. 1994 Jun 15;8(12):1411-22. doi: 10.1101/gad.8.12.1411.
引用本文的文献
1
Defects in the GINS complex increase the instability of repetitive sequences via a recombination-dependent mechanism.GINS 复合物缺陷通过依赖重组的机制增加重复序列的不稳定性。
PLoS Genet. 2019 Dec 9;15(12):e1008494. doi: 10.1371/journal.pgen.1008494. eCollection 2019 Dec.
2
Telomere and Subtelomere R-loops and Antigenic Variation in Trypanosomes.端粒和亚端粒 R 环与锥虫的抗原变异。
J Mol Biol. 2020 Jul 10;432(15):4167-4185. doi: 10.1016/j.jmb.2019.10.025. Epub 2019 Nov 2.
3
Evaluation of mechanisms that may generate DNA lesions triggering antigenic variation in African trypanosomes.评价可能导致抗原变异的非洲锥虫 DNA 损伤触发机制。
PLoS Pathog. 2018 Nov 15;14(11):e1007321. doi: 10.1371/journal.ppat.1007321. eCollection 2018 Nov.
4
Genetic Control of Genomic Alterations Induced in Yeast by Interstitial Telomeric Sequences.酵母中端粒间序列诱导的基因组改变的遗传控制。
Genetics. 2018 Jun;209(2):425-438. doi: 10.1534/genetics.118.300950. Epub 2018 Apr 2.
5
The effects of transcription and recombination on mutational dynamics of short tandem repeats.转录和重组对短串联重复序列突变动态的影响。
Nucleic Acids Res. 2018 Feb 16;46(3):1321-1330. doi: 10.1093/nar/gkx1253.
6
Genome-wide map of Apn1 binding sites under oxidative stress in Saccharomyces cerevisiae.酿酒酵母在氧化应激下Apn1结合位点的全基因组图谱。
Yeast. 2017 Nov;34(11):447-458. doi: 10.1002/yea.3247. Epub 2017 Sep 26.
7
A mononucleotide repeat in PRRT2 is an important, frequent target of mismatch repair deficiency in cancer.PRRT2中的单核苷酸重复序列是癌症中错配修复缺陷的一个重要且常见的靶点。
Oncotarget. 2017 Jan 24;8(4):6043-6056. doi: 10.18632/oncotarget.13464.
8
RNA Polymerase Collision versus DNA Structural Distortion: Twists and Turns Can Cause Break Failure.RNA聚合酶碰撞与DNA结构畸变：扭曲和转折可导致断裂失败。
Mol Cell. 2016 May 5;62(3):327-334. doi: 10.1016/j.molcel.2016.03.034.
9
Mismatch repair enhances convergent transcription-induced cell death at trinucleotide repeats by activating ATR.错配修复通过激活 ATR 增强三核苷酸重复序列处的聚合转录诱导细胞死亡。
DNA Repair (Amst). 2016 Jun;42:26-32. doi: 10.1016/j.dnarep.2016.03.016. Epub 2016 Apr 16.
10
Genome of Cnaphalocrocis medinalis Granulovirus, the First Crambidae-Infecting Betabaculovirus Isolated from Rice Leaffolder to Sequenced.稻纵卷叶螟颗粒体病毒基因组，首个从稻纵卷叶螟中分离得到并测序的夜蛾科β-杆状病毒。
PLoS One. 2016 Feb 5;11(2):e0147882. doi: 10.1371/journal.pone.0147882. eCollection 2016.
本文引用的文献
1
Clues to the pathogenesis of familial colorectal cancer.家族性结直肠癌的发病机制线索。
Science. 1993 May 7;260(5109):812-6. doi: 10.1126/science.8484121.
2
Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair.影响DNA错配修复的突变导致酵母中简单重复DNA片段的不稳定。
Nature. 1993 Sep 16;365(6443):274-6. doi: 10.1038/365274a0.
3
Frequent microsatellite instability in primary small cell lung cancer.原发性小细胞肺癌中频繁的微卫星不稳定性
Cancer Res. 1994 Apr 15;54(8):2098-101.
4
Simple repeat DNA is not replicated simply.简单重复DNA的复制并非易事。
Nat Genet. 1994 Feb;6(2):114-6. doi: 10.1038/ng0294-114.
5
Where transcription meets repair.转录与修复的交汇之处。
Cell. 1994 Apr 8;77(1):9-12. doi: 10.1016/0092-8674(94)90228-3.
6
Some features of base pair mismatch repair and its role in the formation of genetic recombinants.碱基对错配修复的一些特征及其在基因重组体形成中的作用。
Experientia. 1994 Mar 15;50(3):253-60. doi: 10.1007/BF01924008.
7
Instability of simple sequence repeats in a mammalian cell line.
Hum Mol Genet. 1994 Feb;3(2):253-6. doi: 10.1093/hmg/3.2.253.
8
Genetic instability in human ovarian cancer cell lines.人类卵巢癌细胞系中的基因不稳定现象。
Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9495-9. doi: 10.1073/pnas.91.20.9495.
9
DNA damage tolerance, mismatch repair and genome instability.DNA损伤耐受、错配修复与基因组不稳定性
Bioessays. 1994 Nov;16(11):833-9. doi: 10.1002/bies.950161110.
10
Association of increased spontaneous mutation rates with high levels of transcription in yeast.酵母中自发突变率增加与高转录水平的关联。
Science. 1995 Jun 16;268(5217):1616-9. doi: 10.1126/science.7777859.
Zotero 插件