Wierdl M, Greene C N, Datta A, Jinks-Robertson S, Petes T D
Department of Biology, University of North Carolina, Chapel Hill 27599-3280, USA.
Genetics. 1996 Jun;143(2):713-21. doi: 10.1093/genetics/143.2.713.
Simple repetitive DNA sequences in the eukaryotic genome frequently alter in length. In wild-type strains, we find that transcription through a repetitive poly GT tract destabilizes the tract four- to ninefold. In mismatch repair-deficient yeast strains, simple repeats are very unstable. High levels of transcription in such strains destabilize repetitive tracts an additional two- to threefold.
真核生物基因组中的简单重复DNA序列长度经常发生改变。在野生型菌株中，我们发现转录通过一个重复的聚GT序列会使该序列的稳定性降低4至9倍。在错配修复缺陷的酵母菌株中，简单重复序列非常不稳定。在此类菌株中的高转录水平会使重复序列的稳定性再降低2至3倍。
