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Microsatellite instability in yeast: dependence on repeat unit size and DNA mismatch repair genes.酵母中的微卫星不稳定性：对重复单元大小和DNA错配修复基因的依赖性。
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2
Isolation and characterization of point mutations in mismatch repair genes that destabilize microsatellites in yeast.酵母中使微卫星不稳定的错配修复基因点突变的分离与鉴定
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Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair.影响DNA错配修复的突变导致酵母中简单重复DNA片段的不稳定。
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本文引用的文献

1
Hypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants.错配修复和DNA聚合酶校对酵母突变体中同核苷酸序列的高突变性
Mol Cell Biol. 1997 May;17(5):2859-65. doi: 10.1128/MCB.17.5.2859.
2
Frameshift intermediates in homopolymer runs are removed efficiently by yeast mismatch repair proteins.酵母错配修复蛋白可有效去除同聚物序列中的移码中间体。
Mol Cell Biol. 1997 May;17(5):2844-50. doi: 10.1128/MCB.17.5.2844.
3
The prevention of repeat-associated deletions in Saccharomyces cerevisiae by mismatch repair depends on size and origin of deletions.酿酒酵母中错配修复对重复相关缺失的预防取决于缺失的大小和起源。
Genetics. 1996 Aug;143(4):1579-87. doi: 10.1093/genetics/143.4.1579.
4
The Saccharomyces cerevisiae Msh2 and Msh6 proteins form a complex that specifically binds to duplex oligonucleotides containing mismatched DNA base pairs.酿酒酵母的Msh2和Msh6蛋白形成一种复合物，该复合物能特异性结合含有错配DNA碱基对的双链寡核苷酸。
Mol Cell Biol. 1996 Oct;16(10):5604-15. doi: 10.1128/MCB.16.10.5604.
5
Mismatch repair in replication fidelity, genetic recombination, and cancer biology.复制保真度、基因重组及癌症生物学中的错配修复
Annu Rev Biochem. 1996;65:101-33. doi: 10.1146/annurev.bi.65.070196.000533.
6
Binding of insertion/deletion DNA mismatches by the heterodimer of yeast mismatch repair proteins MSH2 and MSH3.酵母错配修复蛋白MSH2和MSH3异二聚体对插入/缺失DNA错配的结合
Curr Biol. 1996 Sep 1;6(9):1185-7. doi: 10.1016/s0960-9822(02)70686-6.
7
hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA.hMutSβ是hMSH2和hMSH3的异源二聚体，可与DNA中的插入/缺失环结合。
Curr Biol. 1996 Sep 1;6(9):1181-4. doi: 10.1016/s0960-9822(02)70685-4.
8
APC mutations in colorectal tumors with mismatch repair deficiency.错配修复缺陷的结直肠肿瘤中的APC突变
Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9049-54. doi: 10.1073/pnas.93.17.9049.
9
Destabilization of simple repetitive DNA sequences by transcription in yeast.酵母中转录导致简单重复DNA序列不稳定
Genetics. 1996 Jun;143(2):713-21. doi: 10.1093/genetics/143.2.713.
10
MSH6, a Saccharomyces cerevisiae protein that binds to mismatches as a heterodimer with MSH2.MSH6，一种酿酒酵母蛋白，它与MSH2形成异二聚体并结合错配序列。
Curr Biol. 1996 Apr 1;6(4):484-6. doi: 10.1016/s0960-9822(02)00516-x.

酵母中的微卫星不稳定性：对重复单元大小和DNA错配修复基因的依赖性。

Microsatellite instability in yeast: dependence on repeat unit size and DNA mismatch repair genes.

作者信息

Sia E A, Kokoska R J, Dominska M, Greenwell P, Petes T D

机构信息

Department of Biology and Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill 27599-3280, USA.

出版信息

Mol Cell Biol. 1997 May;17(5):2851-8. doi: 10.1128/MCB.17.5.2851.

DOI:10.1128/MCB.17.5.2851
PMID:9111357
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC232137/
Abstract

We examined the stability of microsatellites of different repeat unit lengths in Saccharomyces cerevisiae strains deficient in DNA mismatch repair. The msh2 and msh3 mutations destabilized microsatellites with repeat units of 1, 2, 4, 5, and 8 bp; a poly(G) tract of 18 bp was destabilized several thousand-fold by the msh2 mutation and about 100-fold by msh3. The msh6 mutations destabilized microsatellites with repeat units of 1 and 2 bp but had no effect on microsatellites with larger repeats. These results argue that coding sequences containing repetitive DNA tracts will be preferred target sites for mutations in human tumors with mismatch repair defects. We find that the DNA mismatch repair genes destabilize microsatellites with repeat units from 1 to 13 bp but have no effect on the stability of minisatellites with repeat units of 16 or 20 bp. Our data also suggest that displaced loops on the nascent strand, resulting from DNA polymerase slippage, are repaired differently than loops on the template strand.

摘要

我们研究了酿酒酵母中不同重复单元长度的微卫星在DNA错配修复缺陷菌株中的稳定性。msh2和msh3突变使重复单元为1、2、4、5和8个碱基对的微卫星不稳定；msh2突变使18个碱基对的聚（G）序列不稳定数千倍，msh3使其不稳定约100倍。msh6突变使重复单元为1和2个碱基对的微卫星不稳定，但对具有较大重复序列的微卫星没有影响。这些结果表明，含有重复DNA序列的编码序列将是错配修复缺陷的人类肿瘤中突变的首选靶位点。我们发现，DNA错配修复基因使重复单元为1至13个碱基对的微卫星不稳定，但对重复单元为16或20个碱基对的小卫星的稳定性没有影响。我们的数据还表明，由DNA聚合酶滑动导致的新生链上的取代环与模板链上的环修复方式不同。