个体基因组中能够存活至下一代的部分的概率分布。
The probability distribution of the amount of an individual's genome surviving to the following generation.
作者信息
Bickeböller H, Thompson E A
机构信息
INSERM U.155 75016 Paris, France.
出版信息
Genetics. 1996 Jun;143(2):1043-9. doi: 10.1093/genetics/143.2.1043.
The probability that at least p% of an individual's genome is passed on collectively to his children is calculated. With data availability the consideration of the chromosome as a whole rather than discrete loci becomes of increasing practical importance. Assuming the genomic continuum model, which allows for recombination, the crossover process in a chromosome pedigree is viewed as a continuous-time Markov random walk on the vertices of a hypercube with time parameter map distance along the chromosome. The desired probability corresponds to the probability of sojourn times of the process in a small set of vertices, which are well approximated via the Poisson clumping heuristic. Results are given for the human genome. It is very likely that an individual with at least four children passes on at least 90% of his genome. There exists no "equivalent" number of independently segregating loci for this distribution.
计算了个体基因组中至少p%的部分共同传递给其子女的概率。随着数据可得性的提高，将染色体作为一个整体而非离散位点来考虑变得越来越具有实际重要性。假设基因组连续模型（该模型允许重组），染色体谱系中的交叉过程被视为超立方体顶点上的连续时间马尔可夫随机游走，时间参数为沿染色体的图谱距离。所需概率对应于该过程在一小部分顶点上停留时间的概率，可通过泊松聚类启发法很好地近似。给出了人类基因组的结果。一个至少有四个孩子的个体很可能传递其基因组的至少90%。对于这种分布不存在独立分离位点的“等效”数量。
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