Lincoln N B, Faleiro R M, Kelly C, Kirk B A, Jeffcoate W J
Stroke Research Unit, City Hospital, Nottingham, UK.
Diabetes Care. 1996 Jun;19(6):656-8. doi: 10.2337/diacare.19.6.656.
To investigate the relationship between recurrent hypoglycemia and cognitive impairment in insulin-dependent diabetic patients.
Seventy patients who were diagnosed as diabetic at age 18 years or older, were under 55 years old, and had no condition likely to affect cognitive abilities were recruited from a diabetic register. Patients were interviewed to obtain information on the frequency of major and minor hypoglycemia. Their cognitive abilities were assessed on tests of premorbid intelligence, current intelligence, reaction time, concentration, memory, and information processing.
There was a significant correlation between the apparent decline in intelligence, expressed as the discrepancy between the estimated premorbid and the actual performance intelligence quotient, and the frequency of major hypoglycemic attacks (rs = -0.30; P < 0.01). Comparison of patients with and without recurrent hypoglycemia showed few significant differences in cognitive ability.
Results support previous work that suggests that major hypoglycemic attacks have a significant effect on some aspects of cognitive function, but the clinical importance of this finding remains to be determined.
探讨胰岛素依赖型糖尿病患者反复低血糖与认知障碍之间的关系。
从糖尿病登记册中招募了70例年龄在18岁及以上、55岁以下且无可能影响认知能力状况的糖尿病患者。对患者进行访谈以获取有关严重和轻度低血糖发生频率的信息。通过病前智力、当前智力、反应时间、注意力、记忆力和信息处理能力测试对他们的认知能力进行评估。
以估计的病前智商与实际表现智商之间的差异表示的明显智力下降与严重低血糖发作频率之间存在显著相关性（rs = -0.30；P < 0.01）。有反复低血糖和无反复低血糖的患者在认知能力方面几乎没有显著差异。
结果支持先前的研究，即严重低血糖发作对认知功能的某些方面有显著影响，但这一发现的临床重要性仍有待确定。
