Jacqmin-Gadda H, Commenges D, Letenneur L, Dartigues J F
Institut National de la Santé et de la Recherche Médicale U330, Bordeaux, France.
Epidemiology. 1996 May;7(3):281-5. doi: 10.1097/00001648-199605000-00011.
We studied the relation between silica and aluminum levels in drinking water and the risk of cognitive impairment using data from a population-based survey of 3,777 French subjects age 65 years and older. We also studied the effect of pH and the concentrations of calcium, magnesium, fluorine, zinc, copper, and iron. We used a mixed effects logistic regression adjusting for age, sex, educational level, and occupation of the subjects. We confirmed the inverse relation previously found between calcium level and cognitive impairment. We found no important association between cognitive impairment and fluorine, magnesium, iron, copper, or zinc. The association between cognitive impairment and aluminum depended on the pH and the concentration of silica: high levels of aluminum appeared to have a deleterious effect when the silica concentration was low, but there was a protective effect when the pH and the silica level were high. The threshold for an aluminum effect, however, was very low (3.5 micrograms per liter) and did not support the hypothesis of a deleterious effect for only high levels of aluminum.
我们利用一项针对3777名65岁及以上法国人群的基于人群的调查数据，研究了饮用水中二氧化硅和铝含量与认知障碍风险之间的关系。我们还研究了pH值以及钙、镁、氟、锌、铜和铁浓度的影响。我们使用了混合效应逻辑回归模型，并对受试者的年龄、性别、教育水平和职业进行了调整。我们证实了先前发现的钙水平与认知障碍之间的负相关关系。我们发现认知障碍与氟、镁、铁、铜或锌之间没有重要关联。认知障碍与铝之间的关联取决于pH值和二氧化硅浓度：当二氧化硅浓度较低时，高铝水平似乎具有有害影响，但当pH值和二氧化硅水平较高时，则具有保护作用。然而，铝产生影响的阈值非常低（每升3.5微克），并不支持仅高铝水平具有有害影响的假设。
