在同一艾滋病患者中引起脑膜炎和口腔念珠菌病的两株氟康唑耐药白色念珠菌的基因差异
Genetic dissimilarity of two fluconazole-resistant Candida albicans strains causing meningitis and oral candidiasis in the same AIDS patient.
作者信息
Berenguer J, Diaz-Guerra T M, Ruiz-Diez B, Bernaldo de Quiros J C, Rodriguez-Tudela J L, Martinez-Suarez J V
机构信息
Servicio de Microbiología Clínica y Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
出版信息
J Clin Microbiol. 1996 Jun;34(6):1542-5. doi: 10.1128/jcm.34.6.1542-1545.1996.
Abstract
We describe a patient with AIDS who simultaneously developed Candida meningitis with three positive cerebrospinal fluid cultures and oral candidiasis. This patient also had a history or recurrent episodes of oral candidiasis treated with fluconazole. The patient did not respond to this therapy but was cured with amphotericin B and flucytosine. In vitro susceptibility tests revealed that each infection was caused by fluconazole-resistant Candida albicans isolates. Strain delineation by karyotyping, NotI restriction pattern analysis, hybridization with the specific probe 27A, and PCR fingerprinting with the phage M13 core sequence clearly demonstrated that meningitis and oral thrush were caused by two genetically different isolates.
摘要
我们描述了一名艾滋病患者，该患者同时发生了念珠菌性脑膜炎，脑脊液培养三次呈阳性，还伴有口腔念珠菌病。该患者既往有口腔念珠菌病复发史，曾接受氟康唑治疗。患者对该治疗无反应，但使用两性霉素B和氟胞嘧啶治愈。体外药敏试验显示，每种感染均由耐氟康唑的白色念珠菌分离株引起。通过核型分析、NotI限制性酶切图谱分析、与特异性探针27A杂交以及用噬菌体M13核心序列进行PCR指纹图谱分析来鉴定菌株，结果清楚地表明脑膜炎和口腔鹅口疮是由两种基因不同的分离株引起的。
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