Johnson E O, Schütz C G, Anthony J C, Ensminger M E
Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD USA.
Drug Alcohol Depend. 1995 Dec;40(2):159-64. doi: 10.1016/0376-8716(95)01201-x.
Recent cross-sectional studies have indicated that inhalant use might be a vulnerability marker for the development of heroin use. This study is the first prospective investigation of the hypothesized association between early inhalant use and later heroin use. Analyses were conducted using longitudinal data from a community sample of Woodlawn (an all African American community on the South side of Chicago). Six-hundred subjects participated in both the adolescent and the adult assessments (approximately ages 16 and 32, respectively). Youths with a history of inhalant use by age 16 were over nine times more likely to begin heroin use by age 32, even when other plausible risk factors for the development of heroin use were held constant (RR = 9.3; 95% C.I. = 1.3 - 51.3). These findings add to and are consistent with prior cross-sectional evidence from data based on treatment samples and national survey data. The results from this longitudinal assessment support the idea that youthful inhalant use should be regarded as a vulnerability marker for the development of more serious drug use involvement in the form of heroin use.
近期的横断面研究表明，吸入剂使用可能是海洛因使用发展的一个易感性标志物。本研究是对早期吸入剂使用与后期海洛因使用之间假设关联的首次前瞻性调查。分析使用了来自芝加哥南区一个全非裔美国人社区伍德劳恩的社区样本的纵向数据。600名受试者参与了青少年和成人评估（分别约为16岁和32岁）。到16岁时有吸入剂使用史的青少年在32岁前开始使用海洛因的可能性是其他人的九倍多，即使在海洛因使用发展的其他合理风险因素保持不变的情况下（相对风险 = 9.3；95%置信区间 = 1.3 - 51.3）。这些发现补充了基于治疗样本和全国调查数据的先前横断面证据，并且与之相符。这项纵向评估的结果支持这样一种观点，即青少年吸入剂使用应被视为以海洛因使用形式出现的更严重药物使用问题发展的一个易感性标志物。
