重症监护病房中产 TEM-24 型产气肠杆菌的暴发以及超广谱β-内酰胺酶在肠杆菌科其他菌属中的传播。
Outbreak of TEM-24-producing Enterobacter aerogenes in an intensive care unit and dissemination of the extended-spectrum beta-lactamase to other members of the family enterobacteriaceae.
作者信息
Neuwirth C, Siebor E, Lopez J, Pechinot A, Kazmierczak A
机构信息
Laboratoire de Bactériologie, Hôpital Universitaire du Bocage, Dijon, France.
出版信息
J Clin Microbiol. 1996 Jan;34(1):76-9. doi: 10.1128/jcm.34.1.76-79.1996.
Abstract
We report an outbreak of Enterobacter aerogenes in an intensive care unit (ICU) and two medicine departments that produced the extended-spectrum beta-lactamase TEM-24, which was difficult to detect by disk agar diffusion. The strains were compared by DNA restriction fragment length polymorphism after pulsed-field gel electrophoresis following cleavage with XbaI. This typing method indicated that a single strain, first isolated in the ICU, spread throughout the other medical departments as a result of patient transfer. We also observed the transfer in vivo of the plasmid encoding TEM-24 from the strain of Enterobacter aerogenes to different strains of Escherichia coli and Citrobacter freundii in the ICU. It therefore appears that the epidemic involved results from two events: dissemination of one strain of Enterobacter aerogenes and dissemination of the plasmid encoding TEM-24 among various members of the family Enterobacteriaceae.
摘要
我们报告了在一个重症监护病房（ICU）和两个内科病房爆发的产气肠杆菌疫情，这些菌株产生了超广谱β-内酰胺酶TEM-24，通过纸片琼脂扩散法很难检测到。在用XbaI酶切后，通过脉冲场凝胶电泳对菌株进行DNA限制性片段长度多态性分析。这种分型方法表明，最初在ICU分离出的单一菌株，由于患者转移而传播到了其他内科病房。我们还观察到，在ICU中，编码TEM-24的质粒在产气肠杆菌菌株与不同的大肠杆菌和弗氏柠檬酸杆菌菌株之间发生了体内转移。因此，此次疫情似乎是由两个事件导致的：一株产气肠杆菌的传播以及编码TEM-24的质粒在肠杆菌科各成员之间的传播。
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