Offit P A
Children's Hospital of Philadelphia, Pennsylvania, USA.
J Infect Dis. 1996 Sep;174 Suppl 1:S59-64. doi: 10.1093/infdis/174.supplement_1.s59.
Over the past several years, a number of studies have clarified aspects of rotavirus immunology and vaccinology previously considered controversial. In this review, studies that address the following questions will be summarized: Which host factors are responsible for recovery from acute rotavirus infection? Are the host factors responsible for recovery from acute infection the same as those necessary for prevention of infection? What is the relative importance of the nature of the inoculum (e.g., homologous or heterologous host virus and live or inactivated virus), route of inoculation, or virus serotype in vaccine development? What is the immunologic basis by which infection with 1 viral serotype protects against challenge with another serotype (heterotypic protection)?
在过去几年中，一些研究阐明了轮状病毒免疫学和疫苗学中以前被认为有争议的方面。在本综述中，将总结针对以下问题的研究：哪些宿主因素负责从急性轮状病毒感染中恢复？负责从急性感染中恢复的宿主因素与预防感染所需的因素相同吗？接种物的性质（例如，同源或异源宿主病毒以及活病毒或灭活病毒）、接种途径或病毒血清型在疫苗开发中的相对重要性是什么？感染一种病毒血清型可预防另一种血清型攻击（异型保护）的免疫学基础是什么？
