Kato T, Hamakawa H, Shioiri T, Murashita J, Takahashi Y, Takahashi S, Inubushi T
Department of Psychiatry, Shiga University of Medical Science, Japan.
J Psychiatry Neurosci. 1996 Jul;21(4):248-54.
Choline-containing compounds (Cho) were examined by proton magnetic resonance spectroscopy (1H-MRS) in the left subcortical region, including basal ganglia, in 19 euthymic patients with bipolar disorder and 19 age-matched normal controls. Ten of the patients were treated with lithium; the remaining 9 were not treated with lithium for at least 30 d. The Cho to creatine + phosphocreatine (Cr) peak ratio in the bipolar patients (0.75 +/- 0.38 [mean +/- SD]) was higher than that in the normal controls (0.52 +/- 0.26, P < 0.05). There was no significant difference in the Cho:Cr peak ratio between patients treated with lithium (0.63 +/- 0.36) and without lithium (0.89 +/- 0.35). These results do not support the hypothesis that lithium increases the brain choline-containing compounds, but rather imply that membrane breakdown may occur in the basal ganglia of patients with bipolar disorder.
通过质子磁共振波谱法（1H-MRS）对19名双相情感障碍心境正常的患者及19名年龄匹配的正常对照者的左侧皮质下区域（包括基底神经节）中的含胆碱化合物（Cho）进行了检测。其中10名患者接受锂盐治疗；其余9名患者至少30天未接受锂盐治疗。双相情感障碍患者的Cho与肌酸+磷酸肌酸（Cr）的峰比值（0.75±0.38[平均值±标准差]）高于正常对照者（0.52±0.26，P<0.05）。接受锂盐治疗的患者（0.63±0.36）与未接受锂盐治疗的患者（0.89±0.35）的Cho:Cr峰比值无显著差异。这些结果不支持锂盐会增加脑内含胆碱化合物的假说，而是提示双相情感障碍患者的基底神经节可能发生了膜破坏。
