通过穆斯堡尔光谱研究β-血红素形成的化学机制。
The chemical mechanism of beta-haematin formation studied by Mössbauer spectroscopy.
作者信息
Adams P A, Egan T J, Ross D C, Silver J, Marsh P J
机构信息
Department of Chemical Pathology, University of Cape Town, Observatory, South Africa.
出版信息
Biochem J. 1996 Aug 15;318 ( Pt 1)(Pt 1):25-7. doi: 10.1042/bj3180025.
Abstract
Spontaneous formation of beta-haematin (malaria pigment) from haematin in acetate solution follows pseudo-zero-order and not autocatalytic kinetics. Acetate appears to facilitate the reaction by solubilizing the haematin and acting as a phase-transfer catalyst, a role which, in vivo, could be fulfilled by carboxylic acids or amino acids.
摘要
在醋酸盐溶液中，高铁血红素自发形成β-血红素（疟色素）遵循准零级动力学而非自催化动力学。醋酸盐似乎通过溶解高铁血红素并作为相转移催化剂来促进反应，在体内，羧酸或氨基酸可以发挥这一作用。
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本文引用的文献
1
The iron environment in heme and heme-antimalarial complexes of pharmacological interest.具有药理学意义的血红素及血红素-抗疟复合物中的铁环境。
J Inorg Biochem. 1996 Jul;63(1):69-77. doi: 10.1016/0162-0134(95)00212-x.
2
Plasmodium hemozoin formation mediated by histidine-rich proteins.富含组氨酸的蛋白质介导疟原虫疟色素的形成。
Science. 1996 Jan 12;271(5246):219-22. doi: 10.1126/science.271.5246.219.
3
Synthesis of beta-hematin by dehydrohalogenation of hemin.
Biochem Biophys Res Commun. 1993 Jun 15;193(2):504-8. doi: 10.1006/bbrc.1993.1652.
4
Quinoline anti-malarial drugs inhibit spontaneous formation of beta-haematin (malaria pigment).喹啉抗疟药物可抑制β-血红素（疟色素）的自发形成。
FEBS Lett. 1994 Sep 19;352(1):54-7. doi: 10.1016/0014-5793(94)00921-x.
5
Malarial haemozoin/beta-haematin supports haem polymerization in the absence of protein.疟原虫疟色素/β-血红素在无蛋白质存在的情况下支持血红素聚合。
Nature. 1995 Mar 16;374(6519):269-71. doi: 10.1038/374269a0.
6
The feeding mechanism of avian malarial parasites.禽类疟原虫的摄食机制。
J Cell Biol. 1966 Feb;28(2):355-73. doi: 10.1083/jcb.28.2.355.
7
Antimalarials increase vesicle pH in Plasmodium falciparum.抗疟药会提高恶性疟原虫中的囊泡pH值。
J Cell Biol. 1985 Dec;101(6):2302-9. doi: 10.1083/jcb.101.6.2302.
8
Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease.人类疟疾病原体恶性疟原虫中的血红蛋白降解：由一种特定天冬氨酸蛋白酶启动的分解代谢途径。
J Exp Med. 1991 Apr 1;173(4):961-9. doi: 10.1084/jem.173.4.961.
9
An iron-carboxylate bond links the heme units of malaria pigment.一个铁 - 羧酸盐键连接着疟色素的血红素单元。
Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):325-9. doi: 10.1073/pnas.88.2.325.
10
Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites.氯喹对疟原虫滋养体中一种新型血红素聚合酶酶活性的抑制作用。
Nature. 1992 Jan 9;355(6356):167-9. doi: 10.1038/355167a0.
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