Arif M
Department of Pathology (32), King Saud University, Riyadh, Saudi Arabia.
Ann Trop Med Parasitol. 1996 Apr;90(2):197-201. doi: 10.1080/00034983.1996.11813044.
Rates of exposure to two, enterically transmitted viruses, hepatitis E virus (HEV) and hepatitis A virus (HAV), were investigated among the populations of two areas of Saudi Arabia: Gizan (a rural area) and Riyadh (an urban area, with relatively good sanitation). In Riyadh, 24.7% and 1.2% of children were seropositive for HAV and HEV, respectively, by the age of 12 years. There was a sharp increase in exposure to HAV between 13 and 20 years of age (to 63.5%) and most (80.0%) of the subjects aged 50 years had apparently been exposed to HAV. Although seropositivity to HEV also increased with subject age, it only reached 18.8% (in subjects aged > 50 years). The age-specific patterns of exposure to HAV and HEV in Gizan were similar to those in Riyadh but the rates of exposure were generally higher; mean rates of exposure to HAV and HEV were 76.3% and 14.9% in Gizan and 61.3% and 8.37% in Riyadh, respectively. That rates of exposure to HEV in Gizan were almost twice those in Riyadh emphasizes the importance of sanitation as an effective measure in controlling the spread of HEV in developing countries.
在沙特阿拉伯的两个地区——吉赞（一个农村地区）和利雅得（一个城市地区，卫生条件相对较好）的人群中，对两种经肠道传播的病毒——戊型肝炎病毒（HEV）和甲型肝炎病毒（HAV）的暴露率进行了调查。在利雅得，到12岁时，分别有24.7%和1.2%的儿童HAV和HEV血清学呈阳性。13至20岁之间HAV暴露率急剧上升（至63.5%），50岁的大多数（80.0%）受试者显然曾接触过HAV。虽然HEV血清学阳性率也随受试者年龄增加，但仅达到18.8%（在年龄>50岁的受试者中）。吉赞地区HAV和HEV的年龄特异性暴露模式与利雅得相似，但暴露率总体较高；吉赞地区HAV和HEV的平均暴露率分别为76.3%和14.9%，利雅得分别为61.3%和8.37%。吉赞地区HEV暴露率几乎是利雅得的两倍，这凸显了卫生设施作为控制发展中国家HEV传播的有效措施的重要性。
