Dujon B
Unité de Génétique Moléculaire des Levures (URA 1149 CNRS), Paris, France.
Trends Genet. 1996 Jul;12(7):263-70. doi: 10.1016/0168-9525(96)10027-5.
The bakers' yeast, Saccharomyces cerevisiae, a microorganism of major importance for bioindustries, and one of the favored model organisms for basic biological research, is the first eukaryote whose genome is entirely sequenced. Beyond the wealth of novel biological information, it is the extent of what remains to be understood in the genome of a simple unicellular organism that is the most striking result: a significant proportion of yeast genes are orphans of unpredictable function. Offering the possibility of large-scale reverse genetics, yeast will be a powerful model for post-sequencing studies. But geneticists are now faced with the difficulty of asking novel questions.
面包酵母，即酿酒酵母，是一种对生物产业至关重要的微生物，也是基础生物学研究中备受青睐的模式生物之一，它是首个基因组被完全测序的真核生物。除了丰富的新生物学信息外，最引人注目的结果是，在一个简单单细胞生物的基因组中仍有待理解的内容范围：相当一部分酵母基因是功能无法预测的孤立基因。酵母提供了大规模反向遗传学的可能性，将成为测序后研究的有力模式。但遗传学家现在面临提出新问题的困难。
