Levy J
ASFRA B. V., Edam, The Netherlands.
Yeast. 1994 Dec;10(13):1689-706. doi: 10.1002/yea.320101304.
The yeast genome is currently being sequenced by a Consortium of European laboratories, in collaboration with a wider international network of researchers. It is expected that within the next two years Saccharomyces cerevisiae will become the first eukaryotic organism to have been completely genetically mapped and sequenced. This article traces the sequencing enterprise from its beginnings, outlining the intentions, the organisation, and the achievements so far. The tasks which remain are discussed, emphasising the follow-on research into the evolution of primitive karyotypes, and, more particularly, into the nature of novel genes revealed during sequencing. The functional analysis of novel genes is attracting an ever wider community of yeast scientists, so that research which began with a decision to sequence a simple genome promises to remain a focus for international cooperation.
目前，一个由欧洲实验室组成的联盟正与更广泛的国际研究网络合作，对酵母基因组进行测序。预计在未来两年内，酿酒酵母将成为首个完成全基因图谱绘制和测序的真核生物。本文追溯了测序工作的起源，概述了其初衷、组织架构以及迄今取得的成果。文中讨论了仍需完成的任务，重点强调了对原始核型进化的后续研究，尤其是对测序过程中发现的新基因本质的研究。新基因的功能分析吸引了越来越多的酵母科学家，因此，这项始于对简单基因组进行测序的研究有望继续成为国际合作的焦点。
