利用完整的酵母基因组序列。

Exploiting the complete yeast genome sequence.

作者信息

Bassett D E, Basrai M A, Connelly C, Hyland K M, Kitagawa K, Mayer M L, Morrow D M, Page A M, Resto V A, Skibbens R V, Hieter P

机构信息

Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2185, USA.

出版信息

Curr Opin Genet Dev. 1996 Dec;6(6):763-6. doi: 10.1016/s0959-437x(96)80033-5.

DOI:10.1016/s0959-437x(96)80033-5

PMID:8994849

Abstract

The completion of the genome sequence of the budding yeast Saccharomyces cerevisiae marks the dawn of an exciting new era in eukaryotic biology that will bring with it a new understanding of yeast, other model organisms, and human beings. This body of sequence data benefits yeast researchers by obviating the need for piecemeal sequencing of genes, and allows researchers working with other organisms to tap into experimental advantages inherent in the yeast system and learn from functionally characterized yeast gene products which are their proteins of interest. In addition, the yeast post-genome sequence era is serving as a testing ground for powerful new technologies, and proven experimental approaches are being applied for the first time in a comprehensive fashion on a complete eukaryotic gene repertoire.

摘要

酿酒酵母基因组序列的完成标志着真核生物学一个令人兴奋的新时代的到来，这将带来对酵母、其他模式生物和人类的全新认识。这些序列数据使酵母研究人员无需再对基因进行零散测序，从而受益，并且让研究其他生物的人员能够利用酵母系统固有的实验优势，学习那些他们感兴趣的、已进行功能表征的酵母基因产物（即蛋白质）。此外，酵母后基因组序列时代正成为强大新技术的试验场，一些经过验证的实验方法首次被全面应用于完整的真核基因库。