针对非洲猪瘟病毒不同蛋白的中和抗体可抑制病毒的附着和内化。
Neutralizing antibodies to different proteins of African swine fever virus inhibit both virus attachment and internalization.
作者信息
Gómez-Puertas P, Rodríguez F, Oviedo J M, Ramiro-Ibáñez F, Ruiz-Gonzalvo F, Alonso C, Escribano J M
机构信息
Centro de Investigación en Sanidad Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Madrid, Spain.
出版信息
J Virol. 1996 Aug;70(8):5689-94. doi: 10.1128/JVI.70.8.5689-5694.1996.
Abstract
African swine fever virus induces in convalescent pigs antibodies that neutralized the virus before and after binding to susceptible cells, inhibiting both virus attachment and internalization. A further analysis of the neutralization mechanisms mediated by the different viral proteins showed that antibodies to proteins p72 and p54 are involved in the inhibition of a first step of the replication cycle related to virus attachment, while antibodies to protein p30 are implicated in the inhibition of virus internalization.
摘要
非洲猪瘟病毒在康复猪体内诱导产生抗体，这些抗体在与易感细胞结合之前和之后均可中和该病毒，同时抑制病毒的附着和内化。对不同病毒蛋白介导的中和机制进行的进一步分析表明，针对蛋白p72和p54的抗体参与抑制与病毒附着相关的复制周期第一步，而针对蛋白p30的抗体则参与抑制病毒的内化。
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