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采用尿硫酸化胆汁酸直接酶法检测替代血清胆红素检测用于新生儿胆汁淤积症的选择性筛查。

Direct enzymatic assay of urinary sulfated bile acids to replace serum bilirubin testing for selective screening of neonatal cholestasis.

作者信息

Matsui A, Kasano Y, Yamauchi Y, Momoya T, Shimada T, Ishikawa T, Abukawa D, Kimura A, Adachi K, Tazuke Y

机构信息

Department of Pediatrics, Jichi Medical School, Tochigi, Japan.

出版信息

J Pediatr. 1996 Aug;129(2):306-8. doi: 10.1016/s0022-3476(96)70260-3.

DOI:10.1016/s0022-3476(96)70260-3
PMID:8765633
Abstract

Direct enzymatic assay of urinary sulfated bile acids is a sensitive, rapid, minimally invasive, and convenient method of detecting cholestasis in young infants. It may replace measurement of serum direct bilirubin for selective screening for biliary atresia and neonatal hepatitis syndrome at 1 month of age.

摘要

尿硫酸化胆汁酸的直接酶法测定是一种灵敏、快速、微创且便捷的检测婴幼儿胆汁淤积的方法。它可能替代血清直接胆红素测定,用于在1月龄时对胆道闭锁和新生儿肝炎综合征进行选择性筛查。

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Direct enzymatic assay of urinary sulfated bile acids to replace serum bilirubin testing for selective screening of neonatal cholestasis.采用尿硫酸化胆汁酸直接酶法检测替代血清胆红素检测用于新生儿胆汁淤积症的选择性筛查。
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Serum bilirubin fractions in cholestatic pediatric patients: determination with Micronex high-performance liquid chromatography.胆汁淤积性儿科患者的血清胆红素组分:用Micronex高效液相色谱法测定
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Urinary sulfated bile acid analysis for the early detection of biliary atresia in infants.尿硫酸化胆汁酸分析用于婴儿胆道闭锁的早期检测。
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Screening of newborn infants for cholestatic hepatobiliary disease with tandem mass spectrometry.采用串联质谱法对新生儿进行胆汁淤积性肝胆疾病筛查。
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Increased urinary excretion of 3-oxo-delta4 bile acids in Japanese patients with idiopathic neonatal cholestasis.日本特发性新生儿胆汁淤积症患者尿中3-氧代-δ4胆汁酸排泄增加。
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Unconjugated, glycine-conjugated, taurine-conjugated bile acid nonsulfates and sulfates in urine of young infants with cholestasis.胆汁淤积的婴幼儿尿液中未结合型、甘氨酸结合型、牛磺酸结合型胆汁酸非硫酸盐和硫酸盐。
Acta Paediatr Scand. 1984 May;73(3):392-7. doi: 10.1111/j.1651-2227.1994.tb17754.x.

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