Ensor C M, Tai H H
Division of Medicinal Chemistry and Pharmaceutics, University of Kentucky College of Pharmacy, Lexington 40536-0082, USA.
J Lipid Mediat Cell Signal. 1995 Oct;12(2-3):313-9. doi: 10.1016/0929-7855(95)00040-w.
Relatively little is known about how 15-PGDH activity is regulated. Changes in 15-PGDH activity have been reported in response to physiological changes brought about by aging, pregnancy, hormonal changes, hypertension and smoking. In addition a large number of drugs have been shown to affect 15-PGDH activity both in vivo and in vitro. The availability of the 15-PGDH cDNA will be a valuable tool for studying how this enzyme is regulated. Isolation of the genomic DNA with its promoter regions has not yet been reported.
关于15-前列腺素脱氢酶（15-PGDH）的活性是如何被调节的，我们了解得相对较少。据报道，随着衰老、怀孕、激素变化、高血压和吸烟所引起的生理变化，15-PGDH的活性会发生改变。此外，大量药物已被证明在体内和体外均会影响15-PGDH的活性。15-PGDH互补DNA（cDNA）的可得性将成为研究该酶如何被调节的一个有价值的工具。其基因组DNA及其启动子区域的分离尚未见报道。
