来自海洋海绵球状星骨海绵的新型异香树脂烷三萜，可诱导大鼠成纤维细胞发生形态变化。
New isomalabaricane triterpenes from the marine sponge Stelletta globostellata that induce morphological changes in rat fibroblasts.
作者信息
Oku N, Matsunaga S, Wada S i, Watabe S, Fusetani N
机构信息
Laboratory of Aquatic Natural Products Chemistry and Laboratory of Aquatic Molecular Biology and Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
出版信息
J Nat Prod. 2000 Feb;63(2):205-9. doi: 10.1021/np990333d.
Three new isomalabaricane triterpenes, 29-hydroxystelliferin D (2), 3-epi-29-hydroxystelliferin E (3), and 3-epi-29-hydroxystelliferin A (4), were isolated from the marine sponge Stelletta globostellata. Their structures, including absolute stereochemistry, were determined on the basis of spectral data and chemical methods. Rat fibroblasts treated with 0.2 microM of 2-4 exhibited unusual morphological characteristics, followed by death in 5 days.
从海洋海绵球星海绵（Stelletta globostellata）中分离出三种新的异葫芦素三萜，即29-羟基星芒甾醇D（2）、3-表-29-羟基星芒甾醇E（3）和3-表-29-羟基星芒甾醇A（4）。基于光谱数据和化学方法确定了它们的结构，包括绝对立体化学。用0.2微摩尔的2 - 4处理的大鼠成纤维细胞表现出异常的形态特征，随后在5天内死亡。
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