Golub M S, Takeuchi P T, Keen C L, Hendrickx A G, Gershwin M E
Department of Internal Medicine, University of California, Davis 95616, USA.
Am J Clin Nutr. 1996 Dec;64(6):908-15. doi: 10.1093/ajcn/64.6.908.
Lethargy is characteristic of malnourished populations, but little is known about the biologic mechanism or consequences for cognitive performance. In the current experiment, 24-h activity patterns and performance of an attention task were studied in adolescent female monkeys (18-33 mo of age, n = 10/group) under conditions of moderate dietary zinc deprivation (2 micrograms Zn/g diet) and adequate dietary zinc (50 micrograms Zn/g). There were progressive decreases in daytime activity levels in the zinc-deprived group followed by slowing of growth around the time of the growth spurt. Attention performance was also impaired before the onset of growth retardation. Zinc-deprived monkeys failed to show the shift to later initiation of the rest phase of the diurnal cycle seen in controls in late adolescence. These data support previous findings that activity and attention can be affected during early stages of zinc deprivation before the onset of growth retardation.
嗜睡是营养不良人群的特征，但对于其生物学机制或对认知表现的影响却知之甚少。在当前实验中，研究了中度膳食锌缺乏（2微克锌/克饮食）和充足膳食锌（50微克锌/克）条件下，青春期雌性猴子（18 - 33月龄，每组n = 10）的24小时活动模式和一项注意力任务的表现。锌缺乏组的白天活动水平逐渐下降，随后在生长突增期前后生长减缓。在生长迟缓开始之前，注意力表现也受到损害。锌缺乏的猴子没有出现对照组在青春期后期所表现出的昼夜周期休息阶段开始时间延迟的转变。这些数据支持了先前的研究结果，即在生长迟缓开始之前的锌缺乏早期阶段，活动和注意力就可能受到影响。
