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通过三种定量方法测定头孢唑肟、头孢他啶、头孢呋辛、头孢曲松、头孢噻肟和青霉素对肺炎链球菌的体外活性。

In vitro activity of ceftizoxime, ceftazidime, cefuroxime, ceftriaxone, cefotaxime, and penicillin against Streptococcus pneumoniae as determined by three quantitative methods.

作者信息

Barry A L, Brown S D, Fuchs P C

机构信息

Clinical Microbiology Institute, Tualatin, Oregon 97062, USA.

出版信息

Eur J Clin Microbiol Infect Dis. 1996 Apr;15(4):344-6. doi: 10.1007/BF01695670.

DOI:10.1007/BF01695670
PMID:8781889
Abstract

E-test, broth microdilution, and agar dilution susceptibility tests were used to evaluate penicillin and five extended-spectrum cephalosporins against 196 strains of Streptococcus pneumoniae with different levels of penicillin resistance. Oxacillin disk tests corresponded to minimum inhibitory concentrations of penicillin determined by the E-test better than those generated by broth microdilution or agar dilution methods. Relative potency of the study drugs was as follows: cefotaxime = ceftriaxone > penicillin > cefuroxime > ceftizoxime > ceftazidime.

摘要

采用E试验、肉汤微量稀释法和琼脂稀释法药敏试验，评估青霉素和5种广谱头孢菌素对196株不同水平青霉素耐药的肺炎链球菌的抗菌活性。苯唑西林纸片法测定的青霉素最低抑菌浓度与E试验法的结果相符程度优于肉汤微量稀释法或琼脂稀释法。研究药物的相对效价如下：头孢噻肟 = 头孢曲松 > 青霉素 > 头孢呋辛 > 头孢唑肟 > 头孢他啶。

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In vitro activity of ceftizoxime, ceftazidime, cefuroxime, ceftriaxone, cefotaxime, and penicillin against Streptococcus pneumoniae as determined by three quantitative methods.通过三种定量方法测定头孢唑肟、头孢他啶、头孢呋辛、头孢曲松、头孢噻肟和青霉素对肺炎链球菌的体外活性。
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引用本文的文献

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Drugs. 1997 Mar;53(3):483-510. doi: 10.2165/00003495-199753030-00009.

本文引用的文献

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Pneumococcal resistance to beta-lactam antibiotics: a global geographic overview.肺炎球菌对β-内酰胺类抗生素的耐药性：全球地理概况
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Treatment failure with use of a third-generation cephalosporin for penicillin-resistant pneumococcal meningitis: case report and review.使用第三代头孢菌素治疗耐青霉素肺炎球菌性脑膜炎失败：病例报告及文献复习
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Detection of penicillin and extended-spectrum cephalosporin resistance among Streptococcus pneumoniae clinical isolates by use of the E test.使用E试验检测肺炎链球菌临床分离株中对青霉素和超广谱头孢菌素的耐药性。
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In vitro activities of 12 orally administered antimicrobial agents against four species of bacterial respiratory pathogens from U.S. Medical Centers in 1992 and 1993.1992年和1993年12种口服抗菌药物对来自美国医疗中心的四种细菌性呼吸道病原体的体外活性。
Antimicrob Agents Chemother. 1994 Oct;38(10):2419-25. doi: 10.1128/AAC.38.10.2419.
6
Development of interpretive criteria and quality control limits for broth microdilution and disk diffusion antimicrobial susceptibility testing of Streptococcus pneumoniae.肺炎链球菌肉汤微量稀释法和纸片扩散法抗菌药物敏感性试验的解释标准及质量控制限度的制定
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Diminished activity of ceftizoxime in comparison to cefotaxime and ceftriaxone against Streptococcus pneumoniae.与头孢噻肟和头孢曲松相比，头孢唑肟对肺炎链球菌的活性降低。
Clin Infect Dis. 1995 Mar;20(3):671-6. doi: 10.1093/clinids/20.3.671.
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In vitro killing of penicillin-susceptible, -intermediate, and -resistant strains of Streptococcus pneumoniae by cefotaxime, ceftriaxone, and ceftizoxime: a comparison of bactericidal and inhibitory activity with achievable CSF levels.头孢噻肟、头孢曲松和头孢唑肟对青霉素敏感、中介及耐药肺炎链球菌菌株的体外杀伤作用：杀菌和抑菌活性与脑脊液可达到水平的比较
Diagn Microbiol Infect Dis. 1995 May-Jun;22(1-2):35-42. doi: 10.1016/0732-8893(95)00094-q.
9
Screening pneumococci for penicillin resistance.筛查肺炎球菌的青霉素耐药性。
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Treatment and diagnosis of infections caused by drug-resistant Streptococcus pneumoniae.耐多药肺炎链球菌所致感染的治疗与诊断
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