Barry A L, Fuchs P C
Clinical Microbiology Institute, Tualatin, Oregon 97062, USA.
J Clin Microbiol. 1996 Oct;34(10):2609-12. doi: 10.1128/jcm.34.10.2609-2612.1996.
Cefotaxime- and ceftriaxone-resistant Streptococcus pneumoniae is now appearing in some medical centers, but 30-micrograms cefotaxime or 30-micrograms ceftriaxone disks are not reliable for detecting such strains. Studies were undertaken to select another cephalosporin disk that might be used as a screening test that could be used in conjunction with a 1-micrograms oxacillin disk. A 30-micrograms cefuroxime disk is proposed: strains with zones > or = 28 mm in diameter are predictably susceptible to cefotaxime and ceftriaxone, and those with smaller zones should be further studied to confirm resistance to either drug. A 30-micrograms ceftizoxime disk may also be used as a screening test with zones > or = 26 mm indicating susceptibility, but cefuroxime disks are preferred.
耐头孢噻肟和头孢曲松的肺炎链球菌目前正在一些医疗中心出现，但30微克头孢噻肟或30微克头孢曲松纸片对于检测此类菌株并不可靠。已开展研究以选择另一种头孢菌素纸片，该纸片可用作筛查试验，并可与1微克苯唑西林纸片联合使用。建议使用30微克头孢呋辛纸片：直径抑菌圈≥28毫米的菌株可预测对头孢噻肟和头孢曲松敏感，抑菌圈较小的菌株应进一步研究以确认对这两种药物的耐药性。30微克头孢唑肟纸片也可用作筛查试验，抑菌圈≥26毫米表明敏感，但首选头孢呋辛纸片。
