Kusumi A, Sako Y
Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba 3-8-1, Meguro-ku, Tokyo 153, Japan.
Curr Opin Cell Biol. 1996 Aug;8(4):566-74. doi: 10.1016/s0955-0674(96)80036-6.
Single-particle tracking and laser tweezers have facilitated the observation of the mechanics of molecular interactions in the plasma membrane of living cells at the level of single (or a few) molecules at nanometer/piconewton precision. These techniques have recently revealed that the membrane skeleton provides both confining and binding effects on the movement of membrane proteins, and that it can play a pivotal role in the molecular organization of the plasma membrane, especially in the formation of special membrane domains.
单粒子追踪和激光镊子技术有助于在纳米/皮牛顿精度水平上对单个（或少数）分子进行观察，从而了解活细胞质膜中分子相互作用的力学机制。这些技术最近揭示，膜骨架对膜蛋白的运动具有限制和结合作用，并且在质膜的分子组织中，尤其是在特殊膜结构域的形成中，可能起着关键作用。
