Petri M
Scand J Rheumatol. 1996;25(4):191-3. doi: 10.3109/03009749609069986.
Vascular damage in systemic lupus erythematosus (SLE) occurs through vasculitis, premature atherosclerosis, and hypercoagulability (predominantly due to the antiphospholipid antibody syndrome). In the Hopkins Lupus Cohort, a prospective cohort study, the incidence of thrombosis is 2 per 100 person-years of follow-up. Markers of immune-complex mediated injury (high anti-dsDNA and low C3), atherosclerosis (hypertension, hyperlipidemia, homocysteine) and antiphospholipid antibodies (lupus anticoagulant or anticardiolipin) are independent predictors of thrombosis. Hydroxychloroquine use is protective against future thrombosis.
系统性红斑狼疮（SLE）中的血管损伤通过血管炎、过早动脉粥样硬化和高凝状态（主要由于抗磷脂抗体综合征）发生。在一项前瞻性队列研究——霍普金斯狼疮队列中，血栓形成的发生率为每100人年随访2例。免疫复合物介导损伤的标志物（高抗双链DNA和低C3）、动脉粥样硬化（高血压、高脂血症、同型半胱氨酸）和抗磷脂抗体（狼疮抗凝物或抗心磷脂）是血栓形成的独立预测因素。使用羟氯喹可预防未来的血栓形成。
