Izumi T, Sasaki R, Tsunoda S, Hatakeyama M, Koyama H, Shinohara N, Miura Y
Department of Medicine, Jichi Medical School, Tochigi.
Intern Med. 1996 May;35(5):416-8. doi: 10.2169/internalmedicine.35.416.
We report a case of sequential occurrence of hepatocellular carcinoma (HCC) following Waldenström's macroglobulinemia (WM) in the course of chronic liver disease. The diagnosis of WM was made in a 55-year-old man with a history of alcohol abuse. He developed HCC in the course of WM, and hepatitis C virus (HCV) infection was detected by enzyme-linked immunosorbent assay. Recent reports suggest that persistent HCV infection is related to the pathogenesis of B cell malignancy. Chronic liver disease may be associated with the pathogenesis of the double malignancies in the present case.
我们报告1例在慢性肝病病程中，继瓦尔登斯特伦巨球蛋白血症（WM）后发生肝细胞癌（HCC）的病例。一名有酗酒史的55岁男性被诊断为WM。他在WM病程中发生了HCC，通过酶联免疫吸附测定检测到丙型肝炎病毒（HCV）感染。最近的报告表明，持续的HCV感染与B细胞恶性肿瘤的发病机制有关。慢性肝病可能与本病例中双重恶性肿瘤的发病机制相关。
