Collas D M, Malone-Lee J G
Department of Medicine, University College London Medical School, St. Pancras Hospital, UK.
Int Urogynecol J Pelvic Floor Dysfunct. 1996;7(1):24-9. doi: 10.1007/BF01895101.
This study examined changes in bladder sensation which occur with age in women. 1381 women (age range 20-95 years, mean 54.9) with symptoms of lower urinary tract dysfunction underwent urodynamic study. The bladder capacity at which they first became aware of the desire to void was taken as a quantitative measure of bladder sensation. Maximum bladder capacity fell in the eighth and ninth decades (H = 95.84, df = 7, P = 0.00), but by contrast bladder capacity at first desire to void rose progressively in association with age, both in the group as a whole (H = 17.13, df = 7, P = 0.017) and in a subgroup with detrusor instability (n = 952, H = 15.42, df = 7, P = 0.032). This rise in capacity points to a decrease in bladder sensation in association with age. This is not due to neurological disease, anti-muscarinic drugs or oestrogens, as the median capacity at first desire to void of these three subgroups did not differ significantly from that of the group as a whole.
本研究调查了女性膀胱感觉随年龄增长而发生的变化。1381名有下尿路功能障碍症状的女性（年龄范围20 - 95岁，平均54.9岁）接受了尿动力学研究。她们首次意识到有排尿欲望时的膀胱容量被用作膀胱感觉的定量指标。最大膀胱容量在八十和九十岁时下降（H = 95.84，自由度 = 7，P = 0.00），但相比之下，首次有排尿欲望时的膀胱容量随年龄增长而逐渐上升，在整个组中（H = 17.13，自由度 = 7，P = 0.017）以及在逼尿肌不稳定的亚组中（n = 952，H = 15.42，自由度 = 7，P = 0.032）均如此。这种容量的增加表明膀胱感觉随年龄增长而下降。这并非由于神经疾病、抗毒蕈碱药物或雌激素所致，因为这三个亚组首次有排尿欲望时的中位容量与整个组相比并无显著差异。
