Zapf S, Wunder A, Anke T, Klostermeyer D, Steglich W, Shan R, Sterner O, Scheuer W
LB Biotechnologie der Universität, Kaiserslautern, Bundesrepublik Deutschland.
Z Naturforsch C J Biosci. 1996 Jul-Aug;51(7-8):487-91.
A new inhibitor of leukotriene biosynthesis, (+)-10 alpha-hydroxy-4-muurolen-3-one (1), was isolated from fermentations of Favolaschia sp. 87129. Its structure was established by spectroscopic methods. The compound exhibited no antifungal or antibacterial activities. The effects of 1 on leukotriene biosynthesis were compared with (+)-T-cadinol, (-)-3-oxo-T-cadinol, and (+)-3 alpha-hydroxy-T-cadinol, three related sesquiterpenes.
一种新的白三烯生物合成抑制剂，(+)-10α-羟基-4-桉叶-3-酮（1），从真菌Favolaschia sp. 87129的发酵产物中分离得到。其结构通过光谱方法确定。该化合物没有抗真菌或抗菌活性。将化合物1对白三烯生物合成的影响与三种相关倍半萜(+)-T-杜松醇、(-)-3-氧代-T-杜松醇和(+)-3α-羟基-T-杜松醇进行了比较。
