Wilske B, Busch U, Eiffert H, Fingerle V, Pfister H W, Rössler D, Preac-Mursic V
Max-von-Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universität München, Germany.
Med Microbiol Immunol. 1996 Feb;184(4):195-201. doi: 10.1007/BF02456135.
Neuroborreliosis is the most frequent manifestation of the second stage of Lyme borreliosis in Europe. However, only few isolates from the cerebrospinal fluid (CSF) have been characterized with controversial results. A large panel of 36 CSF isolates isolated over a 10-year period in Munich has now been analyzed for their OspA and OspC type, resulting in at least eight different types, respectively. Representatives of the different types cultivated from CSF in Munich have also been isolated from other geographical regions in Europe from CSF or ticks, suggesting a widespread distribution of pathogenic strains. A certain OspA type (type 4) was frequently observed in adults but rarely in children or ticks. Since OspA and OspC are the most promising candidates for a Borrelia vaccine, the considerable heterogeneity found among CSF isolates has important implications for development of a vaccine in Europe.
神经莱姆病是欧洲莱姆病第二阶段最常见的表现形式。然而，仅有少数来自脑脊液（CSF）的分离株得到鉴定，结果存在争议。现已对慕尼黑10年间分离出的36株脑脊液分离株进行了分析，以确定其OspA和OspC类型，结果分别至少有8种不同类型。在慕尼黑从脑脊液中培养出的不同类型的代表菌株，也已从欧洲其他地理区域的脑脊液或蜱虫中分离出来，这表明致病菌株分布广泛。某种OspA类型（4型）在成人中经常出现，但在儿童或蜱虫中很少见。由于OspA和OspC是莱姆病疫苗最有前景的候选抗原，脑脊液分离株中发现的显著异质性对欧洲疫苗的研发具有重要意义。
