Moores Jane
Br J Community Nurs. 2013 Dec;Suppl:S6, S8-11. doi: 10.12968/bjcn.2013.18.sup12.s6.
Vitamin C, also known as ascorbic acid (AA), is involved in all phases of wound healing. In the inflammatory phase it is required for neutrophil apoptosis and clearance. During the proliferative phase, AA contributes towards synthesis, maturation, secretion and degradation of collagen. Deficiencies affect the maturation phase by altering collagen production and scar formation. The body strives to maintain homeostasis of AA, thereby ensuring availability for collagen synthesis. After wounding, plasma and tissue levels of AA diminish and, as a consequence, supplements may be useful for healing, although levels beyond saturation are excreted Clinicians need to be aware of both the nutritional status of patients with either acute or chronic wounds and the possibility of any AA deficiency which may hinder healing.
维生素C，也称为抗坏血酸（AA），参与伤口愈合的各个阶段。在炎症阶段，它是中性粒细胞凋亡和清除所必需的。在增殖阶段，抗坏血酸有助于胶原蛋白的合成、成熟、分泌和降解。缺乏会通过改变胶原蛋白的产生和疤痕形成来影响成熟阶段。身体努力维持抗坏血酸的稳态，从而确保有足够的抗坏血酸用于胶原蛋白合成。受伤后，血浆和组织中的抗坏血酸水平会降低，因此，补充剂可能有助于伤口愈合，不过超过饱和水平的抗坏血酸会被排出体外。临床医生需要了解急性或慢性伤口患者的营养状况以及任何可能阻碍愈合的抗坏血酸缺乏的可能性。
