Russell M B, Iselius L, Ostergaard S, Olesen J
Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark.
Hum Genet. 1998 Feb;102(2):138-40. doi: 10.1007/s004390050666.
We investigated the mode of inheritance of chronic tension-type headache in 122 families. The probands were from the Copenhagen Headache Clinic, Denmark. The criteria of the International Headache Society were used. The patterns of segregation of chronic tension-type headache were assessed by complex segregation analysis performed with the computer program POINTER. Of the 122 probands with chronic tension-type headache, 56 had 71 first-degree relatives with chronic tension-type headache. The complex segregation analysis indicates that chronic tension-type headache has multifactorial inheritance.
我们对122个家庭中慢性紧张型头痛的遗传模式进行了研究。先证者来自丹麦哥本哈根头痛诊所。采用了国际头痛协会的标准。通过使用计算机程序POINTER进行的复杂分离分析，评估慢性紧张型头痛的分离模式。在122名患有慢性紧张型头痛的先证者中，56人有71名患有慢性紧张型头痛的一级亲属。复杂分离分析表明，慢性紧张型头痛具有多因素遗传。
