Wrangskog K, Sollenberg J, Söderman E
National Institute for Working Life, Solna, Sweden.
Int Arch Occup Environ Health. 1996;68(5):337-41. doi: 10.1007/BF00409419.
In biological monitoring of styrene, the exposure is usually related to the urinary concentration of mandelic (MA) and/or phenylglyoxylic (PGA) acids in a urine sample taken after the workshift or on following morning. To study this relationship further, a single-compartment mathematical model was developed by which measured occupational repetitive uptake of styrene during a working day was related to measured excretion rates of the urinary metabolites. The model was used in practice to calculate the unknown uptake (dose) from MA and PGA excretion analyzed in urine samples. For comparison, a styrene limit dose was calculated from the exposure limit. Analytical results of samples from plastic boat builders were compared with the limit values.
在苯乙烯的生物监测中，暴露情况通常与工作日结束时或次日早晨采集的尿液样本中扁桃酸（MA）和/或苯乙醇酸（PGA）的尿浓度相关。为了进一步研究这种关系，建立了一个单室数学模型，通过该模型，工作日期间测得的职业性重复苯乙烯摄入量与测得的尿代谢物排泄率相关。该模型在实际中用于根据尿液样本中分析的MA和PGA排泄量计算未知摄入量（剂量）。作为比较，根据暴露限值计算出苯乙烯限量剂量。将塑料船建造工人样本的分析结果与限值进行了比较。
