23S核糖体RNA的突变与幽门螺杆菌对克拉霉素的耐药性有关。
Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori.
作者信息
Versalovic J, Shortridge D, Kibler K, Griffy M V, Beyer J, Flamm R K, Tanaka S K, Graham D Y, Go M F
机构信息
Division of Digestive Diseases, Baylor College of Medicine, Houston, Texas, USA.
出版信息
Antimicrob Agents Chemother. 1996 Feb;40(2):477-80. doi: 10.1128/AAC.40.2.477.
Abstract
Twelve clarithromycin-resistant Helicobacter pylori isolates (100% of resistant isolates examined) from seven different patients each contained an A-->G transition mutation within a conserved loop of 23S rRNA. A-->G transition mutations at positions cognate with Escherichia coli 23S rRNA positions 2058 and 2059 were identified. Clarithromycin-susceptible H. pylori isolates from 14 different patients displayed no polymorphisms in a conserved loop within domain V of 23S rRNA. The study is the first to report mutations in H. pylori associated with resistance to an antimicrobial agent used in established peptic ulcer treatment regimens.
摘要
从7名不同患者中分离出的12株对克拉霉素耐药的幽门螺杆菌菌株（占所检测耐药菌株的100%），在23S rRNA的一个保守环内均含有A→G转换突变。已鉴定出与大肠杆菌23S rRNA第2058和2059位同源位置的A→G转换突变。来自14名不同患者的对克拉霉素敏感的幽门螺杆菌菌株在23S rRNA结构域V的一个保守环内未显示多态性。该研究首次报道了幽门螺杆菌中与既定消化性溃疡治疗方案中使用的抗菌药物耐药相关的突变。
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