解释幽门螺杆菌临床分离株中与克拉霉素耐药相关的23S rRNA基因突变的偏差。
Explaining the bias in the 23S rRNA gene mutations associated with clarithromycin resistance in clinical isolates of Helicobacter pylori.
作者信息
Debets-Ossenkopp Y J, Brinkman A B, Kuipers E J, Vandenbroucke-Grauls C M, Kusters J G
机构信息
Department of Clinical Microbiology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands.
出版信息
Antimicrob Agents Chemother. 1998 Oct;42(10):2749-51. doi: 10.1128/AAC.42.10.2749.
Abstract
A single point mutation in the 23S rRNA gene of Helicobacter pylori is known to confer resistance to clarithromycin. Most prevalent among clarithromycin-resistant clinical H. pylori isolates are the mutations from A-2142 to G and A-2143 to G in the 23S rRNA gene. The bias in the 23S rRNA gene mutations conferring clarithromycin resistance may result from the higher MIC, stability of resistance, and growth rate found for the strains with the above-mentioned mutations.
摘要
已知幽门螺杆菌23S rRNA基因中的单点突变会导致对克拉霉素耐药。在对克拉霉素耐药的临床幽门螺杆菌分离株中，最常见的23S rRNA基因突变是从A-2142到G以及从A-2143到G。23S rRNA基因突变导致克拉霉素耐药性的偏差可能是由于上述突变菌株具有更高的最低抑菌浓度、耐药稳定性和生长速率。
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