Adebajo A O, Hazelman B L
Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge, U.K.
Clin Exp Rheumatol. 1995 Nov-Dec;13(6):737-40.
Studies conducted in Europe suggest an association between IgG glycosylation abnormalities and rheumatoid arthritis (RA). Glycosylation abnormalities have been shown in other inflammatory diseases such as tuberculosis, systemic lupus erythematosus (SLE) and Crohn's disease. These observations led us to study glycosylation abnormalities among patients with RA and healthy controls in the tropics (sub-Saharan Africa). Using a lectin binding assay, we found that glycosylation differences were present in both groups when compared with British rheumatoid and healthy controls. This suggests that IgG glycosylation abnormalities may occur in association with chronic infections in the tropics.
在欧洲进行的研究表明，IgG糖基化异常与类风湿性关节炎（RA）之间存在关联。在其他炎症性疾病如结核病、系统性红斑狼疮（SLE）和克罗恩病中也已发现糖基化异常。这些观察结果促使我们研究热带地区（撒哈拉以南非洲）类风湿性关节炎患者和健康对照者中的糖基化异常情况。通过凝集素结合测定，我们发现与英国类风湿性关节炎患者和健康对照者相比，这两组均存在糖基化差异。这表明IgG糖基化异常可能与热带地区的慢性感染有关。
