Haller J, Weggemans R M, Ferry M, Guigoz Y
F Hoffmann-La Roche Ltd, Basel, Switzerland.
Eur J Clin Nutr. 1996 Jul;50 Suppl 2:S112-6.
Assessment of the mental health of the European elderly and its correlations with micronutrient plasma levels, education and ability to carry out activities of daily living.
Cross-sectional study.
Eleven small towns in nine European countries.
Randomised sample of 880 subjects of both sexes born in the period 1913 to 1918, stratified according to age and sex.
The mental status was assessed by means of the Mini-Mental State Examination (MMSE) and the 15-item Geriatric Depression Scale (GDS).
The overall mean MMSE score was 26.7 and this was also the mean for both sexes. MMSE scores below 23 were found in 8.5% of the men and 10.9% of the women. The overall mean GDS score was 3.9, 3.2 for the men and 4.6 for the women. GDS scores above the cut-off of 5 were found in 11.6% of the men and 27.5% of the women. There were many correlations between the MMSE and the GDS scores and education, Activities of Daily Living scores, subjective health and plasma micronutrient levels, particularly the carotenoids. No geographical pattern of the distribution of MMSE and GDS scores was discernible.
The overall cognitive function of these elderly subjects aged 74 to 79 years was on the whole well preserved. The GDS scores suggest that the prevalence of depression was high in this sample. Education and higher plasma levels of certain vitamins and carotenoids appear to be associated with lower risk of developing dementia.
评估欧洲老年人的心理健康状况及其与血浆微量营养素水平、教育程度和日常生活活动能力的相关性。
横断面研究。
九个欧洲国家的11个小镇。
随机抽取880名1913年至1918年出生的男女受试者样本，按年龄和性别分层。
通过简易精神状态检查表（MMSE）和15项老年抑郁量表（GDS）评估心理状态。
MMSE总分平均为26.7分，男女平均分相同。男性中8.5%、女性中10.9%的MMSE得分低于23分。GDS总分平均为3.9分，男性为3.2分，女性为4.6分。男性中11.6%、女性中27.5%的GDS得分高于临界值5分。MMSE和GDS得分与教育程度、日常生活活动得分、主观健康状况和血浆微量营养素水平（尤其是类胡萝卜素）之间存在许多相关性。MMSE和GDS得分的分布没有明显的地理模式。
这些74至79岁老年受试者的整体认知功能总体上保存良好。GDS得分表明该样本中抑郁症的患病率较高。教育程度以及某些维生素和类胡萝卜素的较高血浆水平似乎与患痴呆症的较低风险相关。
