Hüfner M, Grussendorf M, Lorenz U, Knöpfle M
Eur J Pediatr. 1977 Jul 1;125(3):213-7. doi: 10.1007/BF00480599.
3,3',5'-triiodothyronine (reverse T3, rT3) was measured in 122 samples of amniotic fluid obtained between the 29th--40th weeks of gestation, and in the blood of 37 newborn and their mothers. The mean rT3 concentration in amniotic fluid was 0.769 +/- 0.47 ng/ml, with a slight decrease from the 29th--40th weeks of gestation which was not statistically significant. Because of the great scatter of rT3 concentrations in amniotic fluid, its estimation does not seem to be useful in prenatal diagnosis of hypothyroidism. The mean rT3 concentration in cord blood (2.62 ng/ml; range 1.4--4.9 ng/ml) was greatly elevated in comparison to the mean maternal level at delivery (0.34 ng/ml; range 0.08--0.69 ng/ml). The possible use of rT3 measurements in cord blood as a screening test for congenital hypothyroidism is discussed.
对妊娠29至40周期间采集的122份羊水样本以及37对新生儿及其母亲的血液样本进行了3,3',5'-三碘甲状腺原氨酸（反式T3，rT3）检测。羊水样本中rT3的平均浓度为0.769±0.47纳克/毫升，在妊娠29至40周期间略有下降，但差异无统计学意义。由于羊水中rT3浓度离散度较大，因此其测定在甲状腺功能减退症的产前诊断中似乎并无用处。与分娩时母亲的平均水平（0.34纳克/毫升；范围0.08至0.69纳克/毫升）相比，脐血中rT3的平均浓度（2.62纳克/毫升；范围1.4至4.9纳克/毫升）大幅升高。本文讨论了脐血中rT3检测作为先天性甲状腺功能减退症筛查试验的潜在用途。
