Kim M Y, Dubin N
Institute of Environmental Medicine and Kaplan Comprehensive Cancer Center, New York University Medical Center, NY 10010, USA.
Arch Environ Contam Toxicol. 1996 Mar;30(3):423-9. doi: 10.1007/BF00212304.
Most studies on the half-lives of environmental contaminants have been based on small sample sizes and a limited number of repeated measurements. In this paper, we address issues of study design and sample size for half-life studies. Useful guidelines are provided for choosing the number of repeats and the optimal time interval between repeats for estimating an individual's half-life with a given level of precision, while minimizing the cost of the study. In addition, sample size and power considerations for studies comparing two population half-lives are investigated. An example is presented using data from a study on polychlorinated biphenyls and breast cancer.
大多数关于环境污染物半衰期的研究都是基于小样本量和有限次数的重复测量。在本文中，我们探讨了半衰期研究的设计和样本量问题。提供了有用的指导方针，用于选择重复次数以及重复之间的最佳时间间隔，以便在给定的精度水平下估计个体的半衰期，同时将研究成本降至最低。此外，还研究了比较两个人群半衰期的研究的样本量和效能考量。使用一项关于多氯联苯与乳腺癌的研究数据给出了一个示例。
