McCormack B M, Weinstein P R
Department of Neurological Surgery, University of California, San Francisco, School of Medicine, USA.
West J Med. 1996 Jul-Aug;165(1-2):43-51.
Cervical spondylosis is caused by degenerative disc disease and usually produces intermittent neck pain in middle-aged and elderly patients. This pain usually responds to activity modification, neck immobilization, isometric exercises, and medication. Neurologic symptoms occur infrequently, usually in patients with congenital spinal stenosis. For these patients, magnetic resonance imaging is the preferred initial diagnostic study. Because involvement of neurologic structures on imaging studies may be asymptomatic, consultation with a neurologist is advised to rule out other neurologic diseases. In most cases of spondylotic radiculopathy, the results of conservative treatment are so favorable that surgical intervention is not considered unless pain persists or unless there is progressive neurologic deficit. If indicated, a surgical procedure may be done through the anterior or posterior cervical spine; results are gratifying, with long-term improvement in 70% to 80% of patients. Cervical spondylotic myelopathy is the most serious and disabling condition of this disease. Because many patients have nonprogressive minor impairment, neck immobilization is a reasonable treatment in patients presenting with minor neurologic findings or in whom an operation is contraindicated. This simple remedy will result in improvement in 30% to 50% of patients. Surgical intervention is indicated for patients presenting with severe or progressive neurologic deficits. Anterior cervical approaches are generally preferred, although there are still indications for laminectomy. Surgical results are modest, with good initial results expected in about 70% of patients. Functional outcome noticeably declines with long-term follow-up, which raises the question of whether, and how much, surgical treatment affects the natural course of the disease. Prospective randomized studies are needed to answer these questions.
颈椎病由椎间盘退变疾病引起,通常在中老年患者中产生间歇性颈部疼痛。这种疼痛通常通过改变活动方式、颈部固定、等长运动和药物治疗得到缓解。神经症状很少见,通常发生在先天性椎管狭窄的患者中。对于这些患者,磁共振成像(MRI)是首选的初始诊断检查。由于影像学检查中神经结构受累可能无症状,建议咨询神经科医生以排除其他神经疾病。在大多数神经根型颈椎病病例中,保守治疗效果良好,除非疼痛持续存在或出现进行性神经功能缺损,否则不考虑手术干预。如果有指征,可通过颈椎前路或后路进行手术;手术效果令人满意,70%至80%的患者可获得长期改善。脊髓型颈椎病是该病最严重且致残的情况。由于许多患者有非进行性轻度损伤,对于有轻度神经学表现或手术禁忌的患者,颈部固定是一种合理的治疗方法。这种简单的治疗方法可使30%至50%的患者病情改善。对于有严重或进行性神经功能缺损的患者,应进行手术干预。一般首选颈椎前路手术,尽管仍有椎板切除术的指征。手术效果一般,约70%的患者预期初期效果良好。长期随访显示功能预后明显下降,这就提出了手术治疗是否以及在多大程度上影响疾病自然病程的问题。需要进行前瞻性随机研究来回答这些问题。