Schopf R E, Ockenfels H M, Morsches B
Department of Dermatology, Johannes Gutenberg University, Mainz, Germany.
Acta Derm Venereol. 1996 Jul;76(4):260-3. doi: 10.2340/0001555576260263.
Ethanol has been reported to exacerbate psoriasis. Since immunological mechanisms are considered to be important for the pathogenesis of psoriasis, we compared the effects of ethanol on lymphocyte proliferation in 15 healthy control individuals and 15 patients with psoriasis. We employed the spontaneous and phytohemagglutin in (PHA)-induced uptake of 3H-TdR to measure lymphocyte proliferation. Ethanol was added to cultures at concentrations ranging from 0.5 to 0.0005% (vol./vol.). We found that both spontaneous and PHA-driven lymphocyte proliferations were significantly lower in patients with psoriasis (P < 0.002). Spontaneous blastogenesis in both controls and patients remained stable under ethanol. In controls, ethanol suppressed the PHA-driven lymphocyte proliferation in a dose-dependent fashion. By contrast, in patients with psoriasis ethanol significantly increased lymphocyte proliferation by 2-3 times (p < 0.002). Our data indicate that in psoriasis the lower lymphocyte transformation is abnormally enhanced by minimal doses of ethanol.
据报道，乙醇会加重银屑病。由于免疫机制被认为对银屑病的发病机制很重要，我们比较了乙醇对15名健康对照个体和15名银屑病患者淋巴细胞增殖的影响。我们采用自发的和植物血凝素（PHA）诱导的3H-TdR摄取来测量淋巴细胞增殖。将乙醇以0.5%至0.0005%（体积/体积）的浓度添加到培养物中。我们发现，银屑病患者的自发和PHA驱动的淋巴细胞增殖均显著降低（P<0.002）。在乙醇作用下，对照组和患者组的自发母细胞形成均保持稳定。在对照组中，乙醇以剂量依赖的方式抑制PHA驱动的淋巴细胞增殖。相比之下，在银屑病患者中，乙醇使淋巴细胞增殖显著增加2至3倍（P<0.002）。我们的数据表明，在银屑病中，最低剂量的乙醇会异常增强较低的淋巴细胞转化。
