Case T S, Saltzman M J, Cheuk J, Yazdani M, Sadeghpour A, Albrecht D, Rossowska M J, Nakamoto T
Department of Physiology, Louisiana State University Medical Center, New Orleans 70119, USA.
Res Exp Med (Berl). 1996;196(3):179-85. doi: 10.1007/BF02576840.
The combined effects of caffeine and alcohol on mineral contents of fetal mandibles and femurs were studied. Pregnant rats were divided into four groups: group 1, control; group 2, caffeine; group 3, alcohol; and group 4, caffeine-plus-alcohol. Alcohol (1.0 g ethanol/kg body weight) was intubated twice daily, beginning at day 9 of gestation. Caffeine (2 mg/100 g body weight) was given as a dietary supplement. Groups 1 and 2 were intubated with isocaloric sucrose solution. At birth, randomly selected pups were killed and the mandible and femur were removed and dried. Ca, P, Mg, Zn and hydroxyproline in these bones were measured. Notwithstanding the dams' intake of caffeine and alcohol administered separately, the present results suggest that the combination of caffeine and alcohol exhibited the most detrimental effects.
研究了咖啡因和酒精对胎儿下颌骨和股骨矿物质含量的联合影响。将怀孕大鼠分为四组：第1组为对照组；第2组为咖啡因组；第3组为酒精组；第4组为咖啡因加酒精组。从妊娠第9天开始，每天给大鼠灌胃酒精（1.0克乙醇/千克体重）两次。咖啡因（2毫克/100克体重）作为膳食补充剂给予。第1组和第2组用等热量蔗糖溶液灌胃。出生时，随机选择幼崽处死，取出下颌骨和股骨并干燥。测量这些骨骼中的钙、磷、镁、锌和羟脯氨酸。尽管母鼠分别摄入了咖啡因和酒精，但目前的结果表明，咖啡因和酒精的组合表现出最有害的影响。
